Clinical Efficacy of Adiponectin-Stimulating Peptide on UV-Induced Skin Damage
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. In Vitro Studies
2.3. Ex Vivo Studies
2.4. Clinical Efficacy Testing
- Pregnant or lactating women, and women with a potential for pregnancy;
- Individuals who used topical steroid-containing dermatological drugs within the past one month for skin disease treatment;
- Participants who have engaged in similar clinical testing within the past 6 months;
- Individuals who have dermatological abnormalities, such as pigmentation spots, acne, erythema, and/or telangiectasia;
- Individuals who have used cosmetics or pharmaceutical products with identical or similar efficacy on the test site within the past 3 months;
- Individuals who received aesthetic procedures on the test site within the past 6 months;
- Other individuals who were considered unsuitable for testing at the principal investigator’s discretion.
2.5. Statistical Analysis
3. Results
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Shin, S.H.; Lee, Y.H.; Rho, N.-K.; Park, K.Y. Skin Aging from Mechanisms to Interventions: Focusing on Dermal Aging. Front. Physiol. 2023, 14, 1195272. [Google Scholar] [CrossRef] [PubMed]
- Bosch, R.; Philips, N.; Suárez-Pérez, J.; Juarranz, A.; Devmurari, A.; Chalensouk-Khaosaat, J.; González, S. Mechanisms of Photoaging and Cutaneous Photocarcinogenesis, and Photoprotective Strategies with Phytochemicals. Antioxidants 2015, 4, 248–268. [Google Scholar] [CrossRef] [PubMed]
- Kruglikov, I.L.; Scherer, P.E. Skin Aging: Are Adipocytes the next Target? Aging 2016, 8, 1457–1469. [Google Scholar] [CrossRef] [PubMed]
- Wollina, U.; Wetzker, R.; Abdel-Naser, M.B.; Kruglikov, I.L. Role of Adipose Tissue in Facial Aging. Clin. Interv. Aging 2017, 12, 2069–2076. [Google Scholar] [CrossRef]
- Kershaw, E.E.; Flier, J.S. Adipose Tissue as an Endocrine Organ. J. Clin. Endocrinol. Metab. 2004, 89, 2548–2556. [Google Scholar] [CrossRef]
- Fasshauer, M.; Blüher, M. Adipokines in Health and Disease. Trends Pharmacol. Sci. 2015, 36, 461–470. [Google Scholar] [CrossRef]
- Oh, J.; Lee, Y.; Oh, S.-W.; Li, T.; Shin, J.; Park, S.-H.; Lee, J. The Role of Adiponectin in the Skin. Biomol. Ther. 2022, 30, 221–231. [Google Scholar] [CrossRef]
- Shibata, S.; Tada, Y.; Asano, Y.; Hau, C.S.; Kato, T.; Saeki, H.; Yamauchi, T.; Kubota, N.; Kadowaki, T.; Sato, S. Adiponectin Regulates Cutaneous Wound Healing by Promoting Keratinocyte Proliferation and Migration via the ERK Signaling Pathway. J. Immunol. 2012, 189, 3231–3241. [Google Scholar] [CrossRef]
- Seo, H.-S.; Seong, K.H.; Kim, C.-D.; Seo, S.J.; Park, B.C.; Kim, M.H.; Hong, S.-P. Adiponectin Attenuates the Inflammation in Atopic Dermatitis-Like Reconstructed Human Epidermis. Ann. Dermatol. 2019, 31, 186–195. [Google Scholar] [CrossRef]
- Suh, J.H.; Lee, Y.; Jin, S.-P.; Kim, E.J.; Seo, E.Y.; Li, N.; Oh, J.-H.; Kim, S.J.; Lee, S.-H.; Lee, D.H.; et al. Adiponectin Prevents Skin Inflammation in Rosacea by Suppressing S6 Phosphorylation in Keratinocytes. J. Investig. Dermatol. 2024, 145, 548–558. [Google Scholar] [CrossRef]
- Ezure, T.; Amano, S. Adiponectin and Leptin Up-regulate Extracellular Matrix Production by Dermal Fibroblasts. BioFactors 2007, 31, 229–236. [Google Scholar] [CrossRef] [PubMed]
- Kim, E.J.; Kim, Y.K.; Kim, M.-K.; Kim, S.; Kim, J.Y.; Lee, D.H.; Chung, J.H. UV-Induced Inhibition of Adipokine Production in Subcutaneous Fat Aggravates Dermal Matrix Degradation in Human Skin. Sci. Rep. 2016, 6, 25616. [Google Scholar] [CrossRef] [PubMed]
- Fang, C.-L.; Huang, L.-H.; Tsai, H.-Y.; Chang, H.-I. Dermal Lipogenesis Inhibits Adiponectin Production in Human Dermal Fibroblasts While Exogenous Adiponectin Administration Prevents against UVA-Induced Dermal Matrix Degradation in Human Skin. Int. J. Mol. Sci. 2016, 17, 1129. [Google Scholar] [CrossRef] [PubMed]
- Lim, C.J.; Lee, Y.-M.; Kang, S.G.; Lim, H.W.; Shin, K.-O.; Jeong, S.K.; Huh, Y.H.; Choi, S.; Kor, M.; Seo, H.S.; et al. Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis. Biomol. Ther. 2017, 25, 511–518. [Google Scholar] [CrossRef]
- Shin, K.-O.; Lim, C.J.; Park, H.Y.; Kim, S.; Kim, B.; Lee, Y.; Chung, H.; Jeong, S.-K.; Park, K.; Park, K. Activation of SIRT1 Enhances Epidermal Permeability Barrier Formation through Ceramide Synthases 2 and 3-Dependent Mechanisms. J. Investig. Dermatol. 2020, 140, 1435–1438. [Google Scholar] [CrossRef]
- Eun, S.; Lim, M.; Jung, J.; Shin, K.; Kim, S.; Kim, Y.; Nam, G.; Jeong, S.; Kim, H. Skin Barrier-Improving and Skin-Soothing Effects of Autophagy-Activating Peptide on Sensitive Skin. Cosmetics 2024, 11, 223. [Google Scholar] [CrossRef]
- Xu, A.; Sweeney, G. Emerging Role of Autophagy in Mediating Widespread Actions of ADIPOQ/Adiponectin. Autophagy 2015, 11, 723–724. [Google Scholar] [CrossRef]
- Zhou, L.; Liu, F. Autophagy Roles in Obesity-Induced ER Stress and Adiponectin Downregulation in Adipocytes. Autophagy 2010, 6, 1196–1197. [Google Scholar] [CrossRef]
- Lee, J.O.; Kim, Y.; Jang, Y.N.; Lee, J.M.; Shin, K.; Jeong, S.; Chung, H.-J.; Kim, B.J. ICP5249 Promotes Hair Growth by Activating the AMPK-Autophagy Signaling Pathway. J. Microbiol. Biotechnol. 2024, 34, 1810–1818. [Google Scholar] [CrossRef]
- Kim, S.; Kim, Y.; Jung, J.; Kim, H.-J.; Jeong, S.; Shin, H.; Ryu, W.-S.; Sohn, J.-H.; Nam, G. Clinical Efficacy of Endocannabinoid-Mimetic Fatty Acid Amide as a Skin-Soothing Ingredient. Cosmetics 2024, 11, 225. [Google Scholar] [CrossRef]
- Safwan-Zaiter, H.; Wagner, N.; Wagner, K.-D. P16INK4A—More Than a Senescence Marker. Life 2022, 12, 1332. [Google Scholar] [CrossRef] [PubMed]
- Ahmed, N. Induced Expression of P16 and P21 Proteins in UVB-Irradiated Human Epidermis and Cultured Keratinocytes. J. Dermatol. Sci. 1999, 19, 175–181. [Google Scholar] [CrossRef] [PubMed]
- Jin, T.; Park, K.Y.; Seo, S.J. Adiponectin Upregulates Filaggrin Expression via SIRT1-Mediated Signaling in Human Normal Keratinocytes. Ann. Dermatol. 2017, 29, 407. [Google Scholar] [CrossRef]
- Liu, M.; Lu, F.; Feng, J. Aging and Homeostasis of the Hypodermis in the Age-Related Deterioration of Skin Function. Cell Death Dis. 2024, 15, 443. [Google Scholar] [CrossRef]
- Shibata, S.; Tada, Y.; Hau, C.S.; Mitsui, A.; Kamata, M.; Asano, Y.; Sugaya, M.; Kadono, T.; Masamoto, Y.; Kurokawa, M.; et al. Adiponectin Regulates Psoriasiform Skin Inflammation by Suppressing IL-17 Production from Γδ-T Cells. Nat. Commun. 2015, 6, 7687. [Google Scholar] [CrossRef]
- Liu, Y.; Palanivel, R.; Rai, E.; Park, M.; Gabor, T.V.; Scheid, M.P.; Xu, A.; Sweeney, G. Adiponectin Stimulates Autophagy and Reduces Oxidative Stress to Enhance Insulin Sensitivity During High-Fat Diet Feeding in Mice. Diabetes 2015, 64, 36–48. [Google Scholar] [CrossRef]
- Hong, S.-P.; Seo, H.-S.; Shin, K.-O.; Park, K.; Park, B.C.; Kim, M.H.; Park, M.; Kim, C.-D.; Seo, S.J. Adiponectin Enhances Human Keratinocyte Lipid Synthesis via SIRT1 and Nuclear Hormone Receptor Signaling. J. Invest. Dermatol. 2019, 139, 573–582. [Google Scholar] [CrossRef]
- Choi, S.Y.; Kim, M.J.; Ahn, G.R.; Park, K.Y.; Lee, M.-K.; Seo, S.J. The Effect of Adiponectin on the Regulation of Filaggrin Expression in Normal Human Epidermal Keratinocytes. Ann. Dermatol. 2018, 30, 645. [Google Scholar] [CrossRef]
- Brandner, J.M. Importance of Tight Junctions in Relation to Skin Barrier Function. In Current Problems in Dermatology; Agner, T., Ed.; S. Karger AG: Basel, Switzerland, 2016; Volume 49, pp. 27–37. ISBN 978-3-318-05585-6. [Google Scholar]
Test Product | Control Product |
---|---|
Aqua | Aqua |
Propanediol | Propanediol |
Diisobutyl adipate | Diisobutyl adipate |
Ethylhexyl triazone | Ethylhexyl triazone |
Diisopropyl sebacate | Diisopropyl sebacate |
Butyloctyl salicylate | Butyloctyl salicylate |
Polymethylsilsesquioxane | Polymethylsilsesquioxane |
Diethylamino Hydroxybenzoyl Hexyl Benzoate | Diethylamino Hydroxybenzoyl Hexyl Benzoate |
Niacinamide | Niacinamide |
Drometrizole Trisiloxane | Drometrizole Trisiloxane |
Methylene Bis-Benzotriazolyl Tetramethylbutylphenol | Methylene Bis-Benzotriazolyl Tetramethylbutylphenol |
Caprylyl Methicone | Caprylyl Methicone |
1,2-hexanediol | 1,2-hexanediol |
Butylene glycol | Butylene glycol |
Panthenol | Panthenol |
Pentylene Glycol | Pentylene Glycol |
Behenyl Alcohol | Behenyl Alcohol |
Polyglyceryl-3 Methylglucose Distearate | Polyglyceryl-3 Methylglucose Distearate |
Polyglyceryl-6 Distearate | Polyglyceryl-6 Distearate |
Decyl Glucoside | Decyl Glucoside |
Tromethamine | Tromethamine |
Candelilla/Jojoba/Rice Bran Polyglyceryl-3 Esters | Candelilla/Jojoba/Rice Bran Polyglyceryl-3 Esters |
Carbomer | Carbomer |
Acrylates/C10-30 Alkyl Acrylate Crosspolymer | Acrylates/C10-30 Alkyl Acrylate Crosspolymer |
Sodium Stearoyl Glutamate | Sodium Stearoyl Glutamate |
Polyacrylate Crosspolymer-6 | Polyacrylate Crosspolymer-6 |
Ethylhexylglycerin | Ethylhexylglycerin |
Adenosine | Adenosine |
Glycerin | Glycerin |
Xanthan Gum | Xanthan Gum |
Tocopherol | Tocopherol |
Pentasodium Tetracarboxymethyl Hexanoyl Dipeptide-12 (100 ppm) | - |
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Kim, Y.; Yoon, S.; Kim, S.; Kim, Y.; Jeong, S.; Kim, H.-j. Clinical Efficacy of Adiponectin-Stimulating Peptide on UV-Induced Skin Damage. Cosmetics 2025, 12, 54. https://doi.org/10.3390/cosmetics12020054
Kim Y, Yoon S, Kim S, Kim Y, Jeong S, Kim H-j. Clinical Efficacy of Adiponectin-Stimulating Peptide on UV-Induced Skin Damage. Cosmetics. 2025; 12(2):54. https://doi.org/10.3390/cosmetics12020054
Chicago/Turabian StyleKim, Yongwoo, Seokjeong Yoon, Sungwoo Kim, Yeonjae Kim, Sekyoo Jeong, and Hyun-jung Kim. 2025. "Clinical Efficacy of Adiponectin-Stimulating Peptide on UV-Induced Skin Damage" Cosmetics 12, no. 2: 54. https://doi.org/10.3390/cosmetics12020054
APA StyleKim, Y., Yoon, S., Kim, S., Kim, Y., Jeong, S., & Kim, H.-j. (2025). Clinical Efficacy of Adiponectin-Stimulating Peptide on UV-Induced Skin Damage. Cosmetics, 12(2), 54. https://doi.org/10.3390/cosmetics12020054