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Circadian Clock Regulation of Hepatic Energy Metabolism Regulatory Circuits

1
Centre for Biological Timing, Department of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK
2
NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK and Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 9DU, UK
*
Author to whom correspondence should be addressed.
Biology 2019, 8(4), 79; https://doi.org/10.3390/biology8040079
Received: 14 September 2019 / Revised: 13 October 2019 / Accepted: 15 October 2019 / Published: 19 October 2019
(This article belongs to the Special Issue Biological Clocks)
The liver is a critical organ of energy metabolism. At least 10% of the liver transcriptome demonstrates rhythmic expression, implying that the circadian clock regulates large programmes of hepatic genes. Here, we review the mechanisms by which this rhythmic regulation is conferred, with a particular focus on the transcription factors whose actions combine to impart liver- and time-specificity to metabolic gene expression. View Full-Text
Keywords: circadian clock; biological rhythms; energy metabolism; liver; REV-ERBα; cryptochrome circadian clock; biological rhythms; energy metabolism; liver; REV-ERBα; cryptochrome
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Hunter, A.L.; Ray, D.W. Circadian Clock Regulation of Hepatic Energy Metabolism Regulatory Circuits. Biology 2019, 8, 79.

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