Next Article in Journal / Special Issue
Mitochondrial Transport and Turnover in the Pathogenesis of Amyotrophic Lateral Sclerosis
Previous Article in Journal / Special Issue
Cardiovascular Manifestations of Mitochondrial Disease
Article Menu
Issue 2 (June) cover image

Export Article

Open AccessReview

From Powerhouse to Perpetrator—Mitochondria in Health and Disease

Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark
Author to whom correspondence should be addressed.
Biology 2019, 8(2), 35;
Received: 2 January 2019 / Revised: 16 February 2019 / Accepted: 5 March 2019 / Published: 11 May 2019
(This article belongs to the Special Issue Mitochondrial Dysfunction in Ageing and Diseases of Ageing)
PDF [1249 KB, uploaded 11 May 2019]


In this review we discuss the interaction between metabolic stress, mitochondrial dysfunction, and genomic instability. Unrepaired DNA damage in the nucleus resulting from excess accumulation of DNA damages and stalled replication can initiate cellular signaling responses that negatively affect metabolism and mitochondrial function. On the other hand, mitochondrial pathologies can also lead to stress in the nucleus, and cause sensitivity to DNA-damaging agents. These are examples of how hallmarks of cancer and aging are connected and influenced by each other to protect humans from disease. View Full-Text
Keywords: mitochondria; cancer; nucleotide metabolism; DNA damage; NAD+ mitochondria; cancer; nucleotide metabolism; DNA damage; NAD+

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Fakouri, N.B.; Hansen, T.L.; Desler, C.; Anugula, S.; Rasmussen, L.J. From Powerhouse to Perpetrator—Mitochondria in Health and Disease. Biology 2019, 8, 35.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Biology EISSN 2079-7737 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top