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From Powerhouse to Perpetrator—Mitochondria in Health and Disease

1
Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
2
Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark
*
Author to whom correspondence should be addressed.
Biology 2019, 8(2), 35; https://doi.org/10.3390/biology8020035
Received: 2 January 2019 / Revised: 16 February 2019 / Accepted: 5 March 2019 / Published: 11 May 2019
(This article belongs to the Special Issue Mitochondrial Dysfunction in Ageing and Diseases of Ageing)
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PDF [1249 KB, uploaded 11 May 2019]
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Abstract

In this review we discuss the interaction between metabolic stress, mitochondrial dysfunction, and genomic instability. Unrepaired DNA damage in the nucleus resulting from excess accumulation of DNA damages and stalled replication can initiate cellular signaling responses that negatively affect metabolism and mitochondrial function. On the other hand, mitochondrial pathologies can also lead to stress in the nucleus, and cause sensitivity to DNA-damaging agents. These are examples of how hallmarks of cancer and aging are connected and influenced by each other to protect humans from disease. View Full-Text
Keywords: mitochondria; cancer; nucleotide metabolism; DNA damage; NAD+ mitochondria; cancer; nucleotide metabolism; DNA damage; NAD+
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Fakouri, N.B.; Hansen, T.L.; Desler, C.; Anugula, S.; Rasmussen, L.J. From Powerhouse to Perpetrator—Mitochondria in Health and Disease. Biology 2019, 8, 35.

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