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CoQ10 and Aging

1
Department of Neurosciences, University of California San Diego, San Diego, CA 92093-0935, USA
2
Department of Pediatrics, University of California San Diego, San Diego, CA 92093-0935, USA
*
Author to whom correspondence should be addressed.
Biology 2019, 8(2), 28; https://doi.org/10.3390/biology8020028
Received: 25 February 2019 / Revised: 10 April 2019 / Accepted: 13 April 2019 / Published: 11 May 2019
(This article belongs to the Special Issue Mitochondrial Dysfunction in Ageing and Diseases of Ageing)
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Abstract

The aging process includes impairment in mitochondrial function, a reduction in anti-oxidant activity, and an increase in oxidative stress, marked by an increase in reactive oxygen species (ROS) production. Oxidative damage to macromolecules including DNA and electron transport proteins likely increases ROS production resulting in further damage. This oxidative theory of cell aging is supported by the fact that diseases associated with the aging process are marked by increased oxidative stress. Coenzyme Q10 (CoQ10) levels fall with aging in the human but this is not seen in all species or all tissues. It is unknown whether lower CoQ10 levels have a part to play in aging and disease or whether it is an inconsequential cellular response to aging. Despite the current lay public interest in supplementing with CoQ10, there is currently not enough evidence to recommend CoQ10 supplementation as an anti-aging anti-oxidant therapy. View Full-Text
Keywords: coenzyme Q10; aging; age-related diseases; mitochondrial dysfunction coenzyme Q10; aging; age-related diseases; mitochondrial dysfunction
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Barcelos, I.P.; Haas, R.H. CoQ10 and Aging. Biology 2019, 8, 28.

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