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Antibiotics 2018, 7(2), 41; https://doi.org/10.3390/antibiotics7020041

Streptomyces Differentiation in Liquid Cultures as a Trigger of Secondary Metabolism

Área de Microbiología, Departamento de Biología Funcional IUOPA, Facultad de Medicina, Universidad de Oviedo, 33006 Oviedo, Spain
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Received: 26 February 2018 / Revised: 9 May 2018 / Accepted: 9 May 2018 / Published: 14 May 2018
(This article belongs to the Special Issue Actinomycetes: The Antibiotics Producers)
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Abstract

Streptomyces is a diverse group of gram-positive microorganisms characterised by a complex developmental cycle. Streptomycetes produce a number of antibiotics and other bioactive compounds used in the clinic. Most screening campaigns looking for new bioactive molecules from actinomycetes have been performed empirically, e.g., without considering whether the bacteria are growing under the best developmental conditions for secondary metabolite production. These screening campaigns were extremely productive and discovered a number of new bioactive compounds during the so-called “golden age of antibiotics” (until the 1980s). However, at present, there is a worrying bottleneck in drug discovery, and new experimental approaches are needed to improve the screening of natural actinomycetes. Streptomycetes are still the most important natural source of antibiotics and other bioactive compounds. They harbour many cryptic secondary metabolite pathways not expressed under classical laboratory cultures. Here, we review the new strategies that are being explored to overcome current challenges in drug discovery. In particular, we focus on those aimed at improving the differentiation of the antibiotic-producing mycelium stage in the laboratory. View Full-Text
Keywords: streptomyces; screening; antibiotics; secondary metabolism; differentiation; elicitors; morphology; liquid cultures streptomyces; screening; antibiotics; secondary metabolism; differentiation; elicitors; morphology; liquid cultures
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Manteca, Á.; Yagüe, P. Streptomyces Differentiation in Liquid Cultures as a Trigger of Secondary Metabolism. Antibiotics 2018, 7, 41.

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