Next Article in Journal
A Qualitative Study on the Design and Implementation of the National Action Plan on Antimicrobial Resistance in the Philippines
Previous Article in Journal
Dietary Bacitracin Methylene Disalicylate Improves Growth Performance by Mediating the Gut Microbiota in Broilers
Previous Article in Special Issue
Nanozybiotics: Nanozyme-Based Antibacterials against Bacterial Resistance
 
 
Article

Antivirulence Agent as an Adjuvant of β-Lactam Antibiotics in Treating Staphylococcal Infections

1
Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
2
Department of Microbiology, Queen Mary Hospital, Hong Kong, China
3
State Key Laboratory of Emerging Infectious Diseases and the Research Centre of Infection and Immunology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
4
Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China
5
Department of Microbiology and Immunology, The University of British Columbia, Vancouver, BC V6T 1Z3, Canada
*
Authors to whom correspondence should be addressed.
Academic Editors: Michal Letek and Volker Behrends
Antibiotics 2022, 11(6), 819; https://doi.org/10.3390/antibiotics11060819
Received: 13 May 2022 / Revised: 15 June 2022 / Accepted: 15 June 2022 / Published: 17 June 2022
Staphylococcus aureus can cause a plethora of life-threatening infections. Antibiotics have been extensively used to treat S. aureus infections. However, when antibiotics are used at sub-inhibitory concentrations, especially for β-lactam antibiotics, they may enhance staphylococcal pathogenicity and exacerbate the infection. The combination of antivirulence agents and antibiotics may be a novel approach to controlling antibiotic-induced S. aureus pathogenicity. We have illustrated that under in vitro conditions, antivirulence agent M21, when administered concurrently with ampicillin, suppressed the expression and production of virulence factors induced by ampicillin. In a mouse peritonitis model, M21 reduced bacterial load irrespective of administration of ampicillin. In a bacteremia model, combinatorial treatment consisting of ampicillin or ceftazidime and M21 increased the survival rate of mice and reduced cytokine abundance, suggesting the suppression of antibiotic-induced virulence by M21. Different from traditional antibiotic adjuvants, an antivirulence agent may not synergistically inhibit bacterial growth in vitro, but effectively benefit the host in vivo. Collectively, our findings from this study demonstrated the benefits of antivirulence–antibiotic combinatorial treatment against S. aureus infections and provide a new perspective on the development of antibiotic adjuvants. View Full-Text
Keywords: MRSA; antibiotics; combination; antivirulence; subinhibitory concentration; adjuvant MRSA; antibiotics; combination; antivirulence; subinhibitory concentration; adjuvant
Show Figures

Figure 1

MDPI and ACS Style

Gao, P.; Wei, Y.; Tai, S.S.C.; Halebeedu Prakash, P.; Iu, H.T.V.; Li, Y.; Yam, H.C.B.; Chen, J.H.K.; Ho, P.L.; Davies, J.; Kao, R.Y.T. Antivirulence Agent as an Adjuvant of β-Lactam Antibiotics in Treating Staphylococcal Infections. Antibiotics 2022, 11, 819. https://doi.org/10.3390/antibiotics11060819

AMA Style

Gao P, Wei Y, Tai SSC, Halebeedu Prakash P, Iu HTV, Li Y, Yam HCB, Chen JHK, Ho PL, Davies J, Kao RYT. Antivirulence Agent as an Adjuvant of β-Lactam Antibiotics in Treating Staphylococcal Infections. Antibiotics. 2022; 11(6):819. https://doi.org/10.3390/antibiotics11060819

Chicago/Turabian Style

Gao, Peng, Yuanxin Wei, Sherlock Shing Chiu Tai, Pradeep Halebeedu Prakash, Ho Ting Venice Iu, Yongli Li, Hin Cheung Bill Yam, Jonathan Hon Kwan Chen, Pak Leung Ho, Julian Davies, and Richard Yi Tsun Kao. 2022. "Antivirulence Agent as an Adjuvant of β-Lactam Antibiotics in Treating Staphylococcal Infections" Antibiotics 11, no. 6: 819. https://doi.org/10.3390/antibiotics11060819

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop