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Brief Report

Concentrations of Ciprofloxacin in the World’s Rivers Are Associated with the Prevalence of Fluoroquinolone Resistance in Escherichia coli: A Global Ecological Analysis

by 1,2
1
HIV/STI Unit, Institute of Tropical Medicine, Antwerp 2000, Belgium
2
Division of Infectious Diseases and HIV Medicine, University of Cape Town, Anzio Road, Observatory, Cape Town 7700, South Africa
Academic Editor: Alain Antonio Ocampo-Sosa
Antibiotics 2022, 11(3), 417; https://doi.org/10.3390/antibiotics11030417
Received: 23 February 2022 / Revised: 17 March 2022 / Accepted: 18 March 2022 / Published: 20 March 2022
Background: Extremely low concentrations of ciprofloxacin may select for antimicrobial resistance. A recent global survey found that ciprofloxacin concentrations exceeded safe levels at 64 sites. In this study, I assessed if national median ciprofloxacin concentrations in rivers were associated with fluoroquinolone resistance in Escherichia coli. Methods: Spearman’s regression was used to assess the country-level association between the national prevalence of fluoroquinolone resistance in E. coli and the median ciprofloxacin concentration in the country’s rivers. Results: The prevalence of fluoroquinolone resistance in E. coli was positively correlated with the concentration of ciprofloxacin in rivers (ρ = 0.36; p = 0.011; n = 48). Discussion: Steps to reducing the concentrations of fluoroquinolones in rivers may help prevent the emergence of resistance in E. coli and other bacterial species. View Full-Text
Keywords: rivers; one health; E. coli; fluoroquinolones; antimicrobial resistance; AMR rivers; one health; E. coli; fluoroquinolones; antimicrobial resistance; AMR
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MDPI and ACS Style

Kenyon, C. Concentrations of Ciprofloxacin in the World’s Rivers Are Associated with the Prevalence of Fluoroquinolone Resistance in Escherichia coli: A Global Ecological Analysis. Antibiotics 2022, 11, 417. https://doi.org/10.3390/antibiotics11030417

AMA Style

Kenyon C. Concentrations of Ciprofloxacin in the World’s Rivers Are Associated with the Prevalence of Fluoroquinolone Resistance in Escherichia coli: A Global Ecological Analysis. Antibiotics. 2022; 11(3):417. https://doi.org/10.3390/antibiotics11030417

Chicago/Turabian Style

Kenyon, Chris. 2022. "Concentrations of Ciprofloxacin in the World’s Rivers Are Associated with the Prevalence of Fluoroquinolone Resistance in Escherichia coli: A Global Ecological Analysis" Antibiotics 11, no. 3: 417. https://doi.org/10.3390/antibiotics11030417

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