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Open AccessArticle

Silk Fibroin-Sheathed Conducting Polymer Wires as Organic Connectors for Biosensors

Department of Chemical and Life Science Engineering, Virginia Commonwealth University, 601 W Main Street, Richmond, VA 23284, USA
College of Environment and Resources, Chongqing Technology and Business University, No.19 Xuefu Avenue, Nanan district, Chongqing 40067, China
Author to whom correspondence should be addressed.
Biosensors 2019, 9(3), 103;
Received: 30 July 2019 / Revised: 14 August 2019 / Accepted: 19 August 2019 / Published: 28 August 2019
Conductive polymers, owing to their tunable mechanical and electrochemical properties, are viable candidates to replace metallic components for the development of biosensors and bioelectronics. However, conducting fibers/wires fabricated from these intrinsically conductive and mechanically flexible polymers are typically produced without protective coatings for physiological environments. Providing sheathed conductive fibers/wires can open numerous opportunities for fully organic biodevices. In this work, we report on a facile method to fabricate core-sheath poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) PEDOT:PSS-silk fibroin conductive wires. The conductive wires are formed through a wet-spinning process, and then coated with an optically transparent, photocrosslinkable silk fibroin sheath for insulation and protection in a facile and scalable process. The sheathed fibers were evaluated for their mechanical and electrical characteristics and overall stability. These wires can serve as flexible connectors to an organic electrode biosensor. The entire, fully organic, biodegradable, and free-standing flexible biosensor demonstrated a high sensitivity and rapid response for the detection of ascorbic acid as a model analyte. The entire system can be proteolytically biodegraded in a few weeks. Such organic systems can therefore provide promising solutions to address challenges in transient devices and environmental sustainability. View Full-Text
Keywords: conducting fiber; flexible; biosensor; PEDOT:PSS; biodegradable conducting fiber; flexible; biosensor; PEDOT:PSS; biodegradable
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MDPI and ACS Style

Jiang, Y.; Xu, M.; Yadavalli, V.K. Silk Fibroin-Sheathed Conducting Polymer Wires as Organic Connectors for Biosensors. Biosensors 2019, 9, 103.

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