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Photoactivatable Aptamer-Based Biosensors for Point-of-Care Testing: Advances and Applications
by
Siyuan Wang
Siyuan Wang
Xinyun Cui
Xinyun Cui
Zixuan Zhong
Zixuan Zhong
Jingjing Zhang
Jingjing Zhang
Dr. Jingjing Zhang holds a Ph.D. in Chemistry from Nanjing University. He is currently an associate [...]
Dr. Jingjing Zhang holds a Ph.D. in Chemistry from Nanjing University. He is currently an associate professor in the School of Chemistry and Chemical Engineering at Nanjing University. Prior to his current position, he was a postdoctoral researcher at the School of Life Sciences, Nanjing University (2011–2012), and a postdoctoral research associate at the University of Illinois at Urbana-Champaign (UIUC, 2012–2018). He then worked at GlucoSentient, Inc., before joining Nanjing University in 2019. Dr. Jingjing Zhang’s research areas include the development and clinical application of portable in vitro diagnostic devices, the design and biomedical applications of PROTAC molecules, and in vivo imaging probes based on functional nucleic acid and gene editing technology.
1
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China
2
School of Life Sciences, Nanjing University, Nanjing 210023, China
*
Author to whom correspondence should be addressed.
Biosensors 2025, 15(6), 336; https://doi.org/10.3390/bios15060336 (registering DOI)
Submission received: 28 April 2025
/
Revised: 22 May 2025
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Accepted: 22 May 2025
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Published: 24 May 2025
Abstract
Photoactivatable aptamer sensing technology is widely used in various detection fields due to its precise spatiotemporal regulation ability, flexible material compatibility, and excellent detection performance. By introducing an optical response mechanism to regulate the efficient recognition of the target by the sensor, this strategy further broadens the regulation means of the aptamer. The application of photoactivated aptamer biosensors in point-of-care testing (POCT) can significantly improve the selectivity, sensitivity, and dynamic response ability of the POCT system. This review systematically explores the design principle and regulation mechanism of photoactivatable aptamers, with a focus on reviewing the application progress of them in the POCT platform. In addition, the existing challenges and future development trends are also discussed. It is expected that this biosensor based on photoactivatable aptamers will continue to drive POCT towards higher sensitivity, intelligence, and scene adaptability, providing innovative tools for precision medicine and environmental health monitoring.
Share and Cite
MDPI and ACS Style
Wang, S.; Cui, X.; Zhong, Z.; Zhang, J.
Photoactivatable Aptamer-Based Biosensors for Point-of-Care Testing: Advances and Applications. Biosensors 2025, 15, 336.
https://doi.org/10.3390/bios15060336
AMA Style
Wang S, Cui X, Zhong Z, Zhang J.
Photoactivatable Aptamer-Based Biosensors for Point-of-Care Testing: Advances and Applications. Biosensors. 2025; 15(6):336.
https://doi.org/10.3390/bios15060336
Chicago/Turabian Style
Wang, Siyuan, Xinyun Cui, Zixuan Zhong, and Jingjing Zhang.
2025. "Photoactivatable Aptamer-Based Biosensors for Point-of-Care Testing: Advances and Applications" Biosensors 15, no. 6: 336.
https://doi.org/10.3390/bios15060336
APA Style
Wang, S., Cui, X., Zhong, Z., & Zhang, J.
(2025). Photoactivatable Aptamer-Based Biosensors for Point-of-Care Testing: Advances and Applications. Biosensors, 15(6), 336.
https://doi.org/10.3390/bios15060336
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