Previous Article in Journal
Cellular Mechanical Phenotypes of Drought-Resistant and Drought-Sensitive Rice Species Distinguished by Double-Resonator Piezoelectric Cytometry Biosensors
Previous Article in Special Issue
Development of a Rapid-Response Fluorescent Probe for H2S: Mechanism Elucidation and Biological Applications
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biosensors
Volume 15
Issue 6
10.3390/bios15060335
biosensors-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Recent Progress on Rare-Earth-Doped Upconversion Nanomaterials for Bioassay Applications

by
Jiling Xu
†,
Hengyuan Cao
†,
Chenwei Wu
,
Ting Wang
,
Liheng Sun
* and
Biao Dong
*
State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Biosensors 2025, 15(6), 335; https://doi.org/10.3390/bios15060335
Submission received: 2 April 2025 / Revised: 13 May 2025 / Accepted: 19 May 2025 / Published: 23 May 2025
(This article belongs to the Special Issue Fluorescent Materials with Excellent Biocompatibility and Their Application in Bio-Sensing, Bio-Imaging (Volume II))
Versions Notes

Abstract

Rare-earth-doped upconversion nanoparticles (UCNPs) have been widely used in biological detection due to their unique anti-Stokes shift, stable chemical properties, tunable emission wavelengths, and low biotoxicity. However, their low fluorescence quantum yield remains a challenge. Constructing a high-performance detection platform based on UCNPs is therefore a critical consideration. Focusing on the biological detection applications of UCNPs, this paper introduces the fundamental principles of upconversion and the design of upconversion fluorescence probes. It then summarizes common strategies for enhancing upconversion luminescence and three biosensing platform formats: solution-based, strip-based, and plate-based. Finally, future directions for UCNPs in biological detection are discussed.
Keywords: rare earth; upconversion; biosensing; FRET rare earth; upconversion; biosensing; FRET

Share and Cite

MDPI and ACS Style

Xu, J.; Cao, H.; Wu, C.; Wang, T.; Sun, L.; Dong, B. Recent Progress on Rare-Earth-Doped Upconversion Nanomaterials for Bioassay Applications. Biosensors 2025, 15, 335. https://doi.org/10.3390/bios15060335

AMA Style

Xu J, Cao H, Wu C, Wang T, Sun L, Dong B. Recent Progress on Rare-Earth-Doped Upconversion Nanomaterials for Bioassay Applications. Biosensors. 2025; 15(6):335. https://doi.org/10.3390/bios15060335

Chicago/Turabian Style

Xu, Jiling, Hengyuan Cao, Chenwei Wu, Ting Wang, Liheng Sun, and Biao Dong. 2025. "Recent Progress on Rare-Earth-Doped Upconversion Nanomaterials for Bioassay Applications" Biosensors 15, no. 6: 335. https://doi.org/10.3390/bios15060335

APA Style

Xu, J., Cao, H., Wu, C., Wang, T., Sun, L., & Dong, B. (2025). Recent Progress on Rare-Earth-Doped Upconversion Nanomaterials for Bioassay Applications. Biosensors, 15(6), 335. https://doi.org/10.3390/bios15060335

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop