Albumin Submicron Particles with Entrapped Riboflavin—Fabrication and Characterization
AbstractAlthough riboflavin (RF) belongs to the water-soluble vitamins of group B, its solubility is low. Therefore, the application of micro-formulations may help to overcome this limiting factor for the delivery of RF. In this study we immobilized RF in newly developed albumin submicron particles prepared using the Co-precipitation Crosslinking Dissolution technique (CCD-technique) of manganese chloride and sodium carbonate in the presence of human serum albumin (HSA) and RF. The resulting RF containing HSA particles (RF-HSA-MPs) showed a narrow size distribution in the range of 0.9 to 1 μm, uniform peanut-like morphology, and a zeta-potential of −15 mV. In vitro release studies represented biphasic release profiles of RF in a phosphate buffered saline (PBS) pH 7.4 and a cell culture medium (RPMI) 1640 medium over a prolonged period. Hemolysis, platelet activation, and phagocytosis assays revealed a good hemocompatibility of RF-HSA-MPs. View Full-Text
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Suwannasom, N.; Smuda, K.; Kloypan, C.; Kaewprayoon, W.; Baisaeng, N.; Prapan, A.; Chaiwaree, S.; Georgieva, R.; Bäumler, H. Albumin Submicron Particles with Entrapped Riboflavin—Fabrication and Characterization. Nanomaterials 2019, 9, 482.
Suwannasom N, Smuda K, Kloypan C, Kaewprayoon W, Baisaeng N, Prapan A, Chaiwaree S, Georgieva R, Bäumler H. Albumin Submicron Particles with Entrapped Riboflavin—Fabrication and Characterization. Nanomaterials. 2019; 9(3):482.Chicago/Turabian Style
Suwannasom, Nittiya; Smuda, Kathrin; Kloypan, Chiraphat; Kaewprayoon, Waraporn; Baisaeng, Nuttakorn; Prapan, Ausanai; Chaiwaree, Saranya; Georgieva, Radostina; Bäumler, Hans. 2019. "Albumin Submicron Particles with Entrapped Riboflavin—Fabrication and Characterization." Nanomaterials 9, no. 3: 482.
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