Next Article in Journal
Hybrid Mesoporous Nanoparticles for pH-Actuated Controlled Release
Previous Article in Journal
Challenges in Determining the Location of Dopants, to Study the Influence of Metal Doping on the Photocatalytic Activities of ZnO Nanopowders
Previous Article in Special Issue
The Effect of Alkyl Chain Number in Sucrose Surfactant on the Physical Properties of Quercetin-Loaded Deformable Nanoliposome and Its Effect on In Vitro Human Skin Penetration
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle

Albumin Submicron Particles with Entrapped Riboflavin—Fabrication and Characterization

1
Institute of Transfusion Medicine, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany
2
School of Medical Sciences, University of Phayao, Phayao 56000, Thailand
3
School of Allied Health Sciences, University of Phayao, Phayao 56000, Thailand
4
Faculty of Pharmacy, Payap University, Chiang Mai 50000, Thailand
5
School of Pharmaceutical Sciences, University of Phayao, Phayao 56000, Thailand
6
Faculty of Allied Health Sciences, Naresuan University, Phitsanulok 65000, Thailand
7
Department of Medical Physics, Biophysics and Radiology, Medical Faculty, Trakia University, 6000 Stara Zagora, Bulgaria
*
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(3), 482; https://doi.org/10.3390/nano9030482
Received: 14 February 2019 / Revised: 15 March 2019 / Accepted: 19 March 2019 / Published: 25 March 2019
(This article belongs to the Special Issue Multifunctional Nanocarriers for Drug Delivery)
  |  
PDF [4504 KB, uploaded 25 March 2019]
  |     |  

Abstract

Although riboflavin (RF) belongs to the water-soluble vitamins of group B, its solubility is low. Therefore, the application of micro-formulations may help to overcome this limiting factor for the delivery of RF. In this study we immobilized RF in newly developed albumin submicron particles prepared using the Co-precipitation Crosslinking Dissolution technique (CCD-technique) of manganese chloride and sodium carbonate in the presence of human serum albumin (HSA) and RF. The resulting RF containing HSA particles (RF-HSA-MPs) showed a narrow size distribution in the range of 0.9 to 1 μm, uniform peanut-like morphology, and a zeta-potential of −15 mV. In vitro release studies represented biphasic release profiles of RF in a phosphate buffered saline (PBS) pH 7.4 and a cell culture medium (RPMI) 1640 medium over a prolonged period. Hemolysis, platelet activation, and phagocytosis assays revealed a good hemocompatibility of RF-HSA-MPs. View Full-Text
Keywords: riboflavin; immobilization; biopolymer; CCD-technique riboflavin; immobilization; biopolymer; CCD-technique
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Suwannasom, N.; Smuda, K.; Kloypan, C.; Kaewprayoon, W.; Baisaeng, N.; Prapan, A.; Chaiwaree, S.; Georgieva, R.; Bäumler, H. Albumin Submicron Particles with Entrapped Riboflavin—Fabrication and Characterization. Nanomaterials 2019, 9, 482.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nanomaterials EISSN 2079-4991 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top