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Open AccessArticle

Albumin Submicron Particles with Entrapped Riboflavin—Fabrication and Characterization

Institute of Transfusion Medicine, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany
School of Medical Sciences, University of Phayao, Phayao 56000, Thailand
School of Allied Health Sciences, University of Phayao, Phayao 56000, Thailand
Faculty of Pharmacy, Payap University, Chiang Mai 50000, Thailand
School of Pharmaceutical Sciences, University of Phayao, Phayao 56000, Thailand
Faculty of Allied Health Sciences, Naresuan University, Phitsanulok 65000, Thailand
Department of Medical Physics, Biophysics and Radiology, Medical Faculty, Trakia University, 6000 Stara Zagora, Bulgaria
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(3), 482;
Received: 14 February 2019 / Revised: 15 March 2019 / Accepted: 19 March 2019 / Published: 25 March 2019
(This article belongs to the Special Issue Multifunctional Nanocarriers for Drug Delivery)
Although riboflavin (RF) belongs to the water-soluble vitamins of group B, its solubility is low. Therefore, the application of micro-formulations may help to overcome this limiting factor for the delivery of RF. In this study we immobilized RF in newly developed albumin submicron particles prepared using the Co-precipitation Crosslinking Dissolution technique (CCD-technique) of manganese chloride and sodium carbonate in the presence of human serum albumin (HSA) and RF. The resulting RF containing HSA particles (RF-HSA-MPs) showed a narrow size distribution in the range of 0.9 to 1 μm, uniform peanut-like morphology, and a zeta-potential of −15 mV. In vitro release studies represented biphasic release profiles of RF in a phosphate buffered saline (PBS) pH 7.4 and a cell culture medium (RPMI) 1640 medium over a prolonged period. Hemolysis, platelet activation, and phagocytosis assays revealed a good hemocompatibility of RF-HSA-MPs. View Full-Text
Keywords: riboflavin; immobilization; biopolymer; CCD-technique riboflavin; immobilization; biopolymer; CCD-technique
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MDPI and ACS Style

Suwannasom, N.; Smuda, K.; Kloypan, C.; Kaewprayoon, W.; Baisaeng, N.; Prapan, A.; Chaiwaree, S.; Georgieva, R.; Bäumler, H. Albumin Submicron Particles with Entrapped Riboflavin—Fabrication and Characterization. Nanomaterials 2019, 9, 482.

AMA Style

Suwannasom N, Smuda K, Kloypan C, Kaewprayoon W, Baisaeng N, Prapan A, Chaiwaree S, Georgieva R, Bäumler H. Albumin Submicron Particles with Entrapped Riboflavin—Fabrication and Characterization. Nanomaterials. 2019; 9(3):482.

Chicago/Turabian Style

Suwannasom, Nittiya; Smuda, Kathrin; Kloypan, Chiraphat; Kaewprayoon, Waraporn; Baisaeng, Nuttakorn; Prapan, Ausanai; Chaiwaree, Saranya; Georgieva, Radostina; Bäumler, Hans. 2019. "Albumin Submicron Particles with Entrapped Riboflavin—Fabrication and Characterization" Nanomaterials 9, no. 3: 482.

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