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Open AccessArticle

The Effect of Alkyl Chain Number in Sucrose Surfactant on the Physical Properties of Quercetin-Loaded Deformable Nanoliposome and Its Effect on In Vitro Human Skin Penetration

1
Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology, 232 Gongneung-ro, Nowon-Gu, Seoul 01811, Korea
2
Skin Care R&D Center, Kolmar Korea Co., Ltd., 12-11, deokgogae-gil, jeonui-myeon, Sejong 30004, Korea
*
Author to whom correspondence should be addressed.
Nanomaterials 2018, 8(8), 622; https://doi.org/10.3390/nano8080622
Received: 25 July 2018 / Revised: 9 August 2018 / Accepted: 14 August 2018 / Published: 16 August 2018
(This article belongs to the Special Issue Multifunctional Nanocarriers for Drug Delivery)
Non-invasive skin penetration of a drug is increased by an edge activator, which enhances the nanoliposome deformability. The objective of this study was to investigate the role of the alkyl chain number of sucrose surfactants as an edge activator in elastic nanoliposomes. In addition, the physicochemical properties of the elastic nanoliposomes were characterized and an in vitro human skin permeation study was performed. Elastic nanoliposomes that were composed of sucrose monostearate (MELQ), sucrose distearate (DELQ), and sucrose tristearte (TELQ) were prepared using a thin-film hydration method. Particle size and entrapment efficiency of elastic nanoliposomes increased proportionally with an increase in the amounts and the numbers of the stearate in sucrose surfactant. Deformability of elastic nanoliposomes was indicated as DELQ > MELQ > TELQ and the same pattern was revealed through the in vitro human skin permeability tests. These results suggest that the number of alkyl chains of sucrose surfactant as edge activator affects the physicochemical property, stability, and skin permeability in elastic nanoliposome. Our findings give a valuable platform for the development of elastic nanoliposomes as skin drug delivery systems. View Full-Text
Keywords: elastic nanoliposome; edge activator; skin drug delivery system; sucrose stearate; deformability elastic nanoliposome; edge activator; skin drug delivery system; sucrose stearate; deformability
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MDPI and ACS Style

Hong, I.K.; Ha, J.H.; Han, S.; Kang, H.; Park, S.N. The Effect of Alkyl Chain Number in Sucrose Surfactant on the Physical Properties of Quercetin-Loaded Deformable Nanoliposome and Its Effect on In Vitro Human Skin Penetration. Nanomaterials 2018, 8, 622. https://doi.org/10.3390/nano8080622

AMA Style

Hong IK, Ha JH, Han S, Kang H, Park SN. The Effect of Alkyl Chain Number in Sucrose Surfactant on the Physical Properties of Quercetin-Loaded Deformable Nanoliposome and Its Effect on In Vitro Human Skin Penetration. Nanomaterials. 2018; 8(8):622. https://doi.org/10.3390/nano8080622

Chicago/Turabian Style

Hong, In K.; Ha, Ji H.; Han, Sangkeun; Kang, Hakhee; Park, Soo N. 2018. "The Effect of Alkyl Chain Number in Sucrose Surfactant on the Physical Properties of Quercetin-Loaded Deformable Nanoliposome and Its Effect on In Vitro Human Skin Penetration" Nanomaterials 8, no. 8: 622. https://doi.org/10.3390/nano8080622

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