Next Article in Journal
Fluorescence and Cytotoxicity of Cadmium Sulfide Quantum Dots Stabilized on Clay Nanotubes
Next Article in Special Issue
A Microfluidic Platform to Study Astrocyte Adhesion on Nanoporous Gold Thin Films
Previous Article in Journal
Incorporation of Levodopa into Biopolymer Coatings Based on Carboxylated Carbon Nanotubes for pH-Dependent Sustained Release Drug Delivery
Previous Article in Special Issue
High Temperature Flow Behavior of Ultra-Strong Nanoporous Au assessed by Spherical Nanoindentation
Open AccessArticle

(9R)-9-Hydroxystearate-Functionalized Anticancer Ceramics Promote Loading of Silver Nanoparticles

Department of Chemistry “Giacomo Ciamician”, University of Bologna, via Selmi, 2, 40126 Bologna, Italy
Department of Industrial Chemistry “Toso Montanari”, Via del Risorgimento, 4, 40136 Bologna, Italy
Authors to whom correspondence should be addressed.
Nanomaterials 2018, 8(6), 390;
Received: 3 May 2018 / Revised: 25 May 2018 / Accepted: 29 May 2018 / Published: 31 May 2018
(This article belongs to the Special Issue Nanoporous Gold and Other Related Materials)
PDF [2104 KB, uploaded 1 June 2018]


Functionalization of calcium phosphates for biomedical applications has been proposed as a strategy to enrich the good osteoinductive properties of these materials with specific therapeutic characteristics. Herein, we prepared and characterized hydroxyapatite nanocrystals functionalized with an anticancer agent, (9R)-9-hydroxystearate (HSA), and loaded with an antimicrobial agent, namely silver nanoparticles (AgNPs). Nanocrystals at two different contents of HSA, about 4 and 9 wt %, were prepared via direct synthesis in aqueous solution. Loading with the antibacterial agent was achieved through interaction with different volumes of AgNPs suspensions. The amount of loaded nanoparticles increases with the volume of the AgNPs suspension and with the hydroxystearate content of the nanocrystals, up to about 3.3 wt %. The structural, morphological, and hydrophobic properties of the composite materials depend on hydroxystearate content, whereas they are not affected by AgNPs loading. At variance, the values of zeta potential slightly increase with the content of AgNPs, which exhibit a sustained release in cell culture medium. View Full-Text
Keywords: hydroxyapatite; silver; nanoparticles; X-ray diffraction; transmission electron microscopy; ceramic; biomaterial hydroxyapatite; silver; nanoparticles; X-ray diffraction; transmission electron microscopy; ceramic; biomaterial

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Boanini, E.; Cassani, M.C.; Rubini, K.; Boga, C.; Bigi, A. (9R)-9-Hydroxystearate-Functionalized Anticancer Ceramics Promote Loading of Silver Nanoparticles. Nanomaterials 2018, 8, 390.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nanomaterials EISSN 2079-4991 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top