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Nanomaterials 2018, 8(6), 382; https://doi.org/10.3390/nano8060382

Antibacterial and Cytotoxic Potential of Biosynthesized Silver Nanoparticles by Some Plant Extracts

Department of Biology, Faculty of Sciences, Princess Nourah Bint Abdulrahman University, 11474 Riyadh, Saudi Arabia
This author is the principal investigator of this work.
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Author to whom correspondence should be addressed.
Received: 7 May 2018 / Revised: 19 May 2018 / Accepted: 26 May 2018 / Published: 30 May 2018
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Abstract

The provision of nanoparticles using biogenic material as a part of green chemistry is an attractive nanotechnology. The current research aimed to test the antimicrobial and cytotoxic efficacy of silver nanoparticles synthesized by extracts of Phoenix dactylifera, Ferula asafetida, and Acacia nilotica as reductant and stabilizing agents in silver nanoparticle formation. Synthesized nanoparticles were evaluated for their antimicrobial activity against Staphylococcus aureus (Gram-positive) and Pseudomonas aeruginosa and Escherichia coli (Gram-negative) using an agar well diffusion assay. Furthermore, cytotoxic ability was investigated against LoVo cells. The potential phyto-constituents of plant extracts were identified by Fourier-transform infrared spectroscopy (FT-IR) techniques. Field emission scanning electron microscopy (FE-SEM), transmission electron microscope (TEM), and zeta potential analyzed the size and morphology of the biogenic nanoparticles. The current study revealed the ability of the tested plant extract to convert silver ions to silver nanoparticles with an average size that ranged between 67.8 ± 0.3 and 155.7 ± 1.5 nm in diameter. Biogenic AgNPs showed significant antibacterial ability (10 to 32 mm diameter) and anticancer ability against a LoVo cell with IC50 ranged between 35.15–56.73 μg/mL. The innovation of the present study is that the green synthesis of NPs, which is simple and cost effective, provides stable nano-materials and can be an alternative for the large-scale synthesis of silver nanoparticles. View Full-Text
Keywords: AgNPs; Phoenix dactylifera; Acacia nilotica; Ferula asafoetida; antibacterial; cytotoxicity AgNPs; Phoenix dactylifera; Acacia nilotica; Ferula asafoetida; antibacterial; cytotoxicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Mohammed, A.E.; Al-Qahtani, A.; al-Mutairi, A.; Al-Shamri, B.; Aabed, K. Antibacterial and Cytotoxic Potential of Biosynthesized Silver Nanoparticles by Some Plant Extracts. Nanomaterials 2018, 8, 382.

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