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Review

Strategies to Build Hybrid Protein–DNA Nanostructures

Laboratory of Biomolecular Engineering and Bionanotechnology, Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México 04510, Mexico
Academic Editor: Silvia Hernández-Ainsa
Nanomaterials 2021, 11(5), 1332; https://doi.org/10.3390/nano11051332
Received: 3 March 2021 / Revised: 24 March 2021 / Accepted: 14 May 2021 / Published: 18 May 2021
(This article belongs to the Special Issue The Application of DNA Nanotechnology)
Proteins and DNA exhibit key physical chemical properties that make them advantageous for building nanostructures with outstanding features. Both DNA and protein nanotechnology have growth notably and proved to be fertile disciplines. The combination of both types of nanotechnologies is helpful to overcome the individual weaknesses and limitations of each one, paving the way for the continuing diversification of structural nanotechnologies. Recent studies have implemented a synergistic combination of both biomolecules to assemble unique and sophisticate protein–DNA nanostructures. These hybrid nanostructures are highly programmable and display remarkable features that create new opportunities to build on the nanoscale. This review focuses on the strategies deployed to create hybrid protein–DNA nanostructures. Here, we discuss strategies such as polymerization, spatial directing and organizing, coating, and rigidizing or folding DNA into particular shapes or moving parts. The enrichment of structural DNA nanotechnology by incorporating protein nanotechnology has been clearly demonstrated and still shows a large potential to create useful and advanced materials with cell-like properties or dynamic systems. It can be expected that structural protein–DNA nanotechnology will open new avenues in the fabrication of nanoassemblies with unique functional applications and enrich the toolbox of bionanotechnology. View Full-Text
Keywords: DNA nanotechnology; protein nanotechnology; self-assembly; bionanomaterials DNA nanotechnology; protein nanotechnology; self-assembly; bionanomaterials
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MDPI and ACS Style

Hernandez-Garcia, A. Strategies to Build Hybrid Protein–DNA Nanostructures. Nanomaterials 2021, 11, 1332. https://doi.org/10.3390/nano11051332

AMA Style

Hernandez-Garcia A. Strategies to Build Hybrid Protein–DNA Nanostructures. Nanomaterials. 2021; 11(5):1332. https://doi.org/10.3390/nano11051332

Chicago/Turabian Style

Hernandez-Garcia, Armando. 2021. "Strategies to Build Hybrid Protein–DNA Nanostructures" Nanomaterials 11, no. 5: 1332. https://doi.org/10.3390/nano11051332

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