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Article

Impact of Citrate and Lipid-Functionalized Magnetic Nanoparticles in Dehydropeptide Supramolecular Magnetogels: Properties, Design and Drug Release

1
Centro de Física (CFUM), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
2
Institute for Polymers and Composites, Department of Polymer Engineering, University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal
3
Centro de Química (CQUM), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
4
Departamento de Física Aplicada, Universidade de Vigo, 36310 Vigo, Spain
5
CINBIO, Universidade de Vigo, 36310 Vigo, Spain
*
Author to whom correspondence should be addressed.
Nanomaterials 2021, 11(1), 16; https://doi.org/10.3390/nano11010016
Received: 29 November 2020 / Revised: 17 December 2020 / Accepted: 21 December 2020 / Published: 23 December 2020
(This article belongs to the Special Issue Nanomaterials for Biomedical and Biotechnological Applications)
Currently, the nanoparticle functionalization effect on supramolecular peptide-based hydrogels remains undescribed, but is expected to affect the hydrogels’ self-assembly and final magnetic gel properties. Herein, two different functionalized nanoparticles: citrate-stabilized (14.4 ± 2.6 nm) and lipid-coated (8.9 ± 2.1 nm) magnetic nanoparticles, were used for the formation of dehydropeptide-based supramolecular magnetogels consisting of the ultra-short hydrogelator Cbz-L-Met-Z-ΔPhe-OH, with an assessment of their effect over gel properties. The lipid-coated nanoparticles were distributed along the hydrogel fibers, while citrate-stabilized nanoparticles were aggregated upon gelation, which resulted into a heating efficiency improvement and decrease, respectively. Further, the lipid-coated nanoparticles did not affect drug encapsulation and displayed improved drug release reproducibility compared to citrate-stabilized nanoparticles, despite the latter attaining a stronger AMF-trigger. This report points out that adsorption of nanoparticles to hydrogel fibers, which display domains that improve or do not affect drug encapsulation, can be explored as a means to optimize the development of supramolecular magnetogels to advance theranostic applications. View Full-Text
Keywords: magnetic gels; drug release; magnetic hyperthermia; magnetic lipogels; supramolecular hydrogels; magnetic nanoparticles; self-assembly; nanoparticle functionalization magnetic gels; drug release; magnetic hyperthermia; magnetic lipogels; supramolecular hydrogels; magnetic nanoparticles; self-assembly; nanoparticle functionalization
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MDPI and ACS Style

Veloso, S.R.S.; Silva, J.F.G.; Hilliou, L.; Moura, C.; Coutinho, P.J.G.; Martins, J.A.; Testa-Anta, M.; Salgueiriño, V.; Correa-Duarte, M.A.; Ferreira, P.M.T.; Castanheira, E.M.S. Impact of Citrate and Lipid-Functionalized Magnetic Nanoparticles in Dehydropeptide Supramolecular Magnetogels: Properties, Design and Drug Release. Nanomaterials 2021, 11, 16. https://doi.org/10.3390/nano11010016

AMA Style

Veloso SRS, Silva JFG, Hilliou L, Moura C, Coutinho PJG, Martins JA, Testa-Anta M, Salgueiriño V, Correa-Duarte MA, Ferreira PMT, Castanheira EMS. Impact of Citrate and Lipid-Functionalized Magnetic Nanoparticles in Dehydropeptide Supramolecular Magnetogels: Properties, Design and Drug Release. Nanomaterials. 2021; 11(1):16. https://doi.org/10.3390/nano11010016

Chicago/Turabian Style

Veloso, Sérgio R.S., Joana F.G. Silva, Loic Hilliou, Cacilda Moura, Paulo J.G. Coutinho, José A. Martins, Martín Testa-Anta, Verónica Salgueiriño, Miguel A. Correa-Duarte, Paula M.T. Ferreira, and Elisabete M.S. Castanheira. 2021. "Impact of Citrate and Lipid-Functionalized Magnetic Nanoparticles in Dehydropeptide Supramolecular Magnetogels: Properties, Design and Drug Release" Nanomaterials 11, no. 1: 16. https://doi.org/10.3390/nano11010016

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