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Article

Ferulic Acid-NLC with Lavandula Essential Oil: A Possible Strategy for Wound-Healing?

by
Claudia Carbone
1,*,
Carla Caddeo
2,
Maria Aurora Grimaudo
3,
Daniela Erminia Manno
4,
Antonio Serra
4 and
Teresa Musumeci
1
1
Laboratory of Drug Delivery Technology, Department of Drug Sciences, University of Catania, viale A. Doria 6, 95125 Catania, Italy
2
Department of Scienze della Vita e dell’Ambiente, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy
3
Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
4
Dipartimento di Matematica e Fisica, University of Salento, 73100 Lecce, Italy
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(5), 898; https://doi.org/10.3390/nano10050898
Submission received: 26 February 2020 / Revised: 17 April 2020 / Accepted: 24 April 2020 / Published: 8 May 2020
(This article belongs to the Special Issue Nanoencapsulation Strategies for Active Compounds Delivery)
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Abstract

Nowadays, an increasing interest in combinatorial drug delivery systems is emerging, highlighting the possibility of exploiting essential oils (EO) for topical applications. This work aimed at developing nanostructured lipid carriers (NLC) for the combined delivery of ferulic acid and Lavandula EO, whose beneficial effects in wound-healing processes have been widely reported. Homogeneous (polydispersity index, PDI < 0.2) nanoparticles with a small size (<150 nm) and a high encapsulation efficiency (>85%) were obtained. The co-presence of ferulic acid and Lavandula EO, as compared to synthetic isopropyl myristate-based NLC, increased nanoparticles’ stability, due to higher ordering chains, as confirmed by morphological and physicochemical studies. An enhanced cytocompatibility was observed when combining ferulic acid and Lavandula EO, as confirmed by in vitro studies on fibroblasts. Furthermore, the combined delivery of ferulic acid and Lavandula EO significantly promoted cell migration with higher effectiveness in respect to the free drug solution and the carrier without the EO. Taken all together, our results suggest a potential combined effect of the antioxidant ferulic acid and Lavandula EO co-delivered in lipid nanoparticles in promoting cell proliferation and migration, representing a promising strategy in the treatment of wounds.
Keywords: Lavandula x intermedia “Sumian”; complementary and alternative medicine; combined delivery; cryo-TEM; cytocompatibility; 2,2-diphenyl-1-picrylhydrazyl (DPPH); migration test Lavandula x intermedia “Sumian”; complementary and alternative medicine; combined delivery; cryo-TEM; cytocompatibility; 2,2-diphenyl-1-picrylhydrazyl (DPPH); migration test

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MDPI and ACS Style

Carbone, C.; Caddeo, C.; Grimaudo, M.A.; Manno, D.E.; Serra, A.; Musumeci, T. Ferulic Acid-NLC with Lavandula Essential Oil: A Possible Strategy for Wound-Healing? Nanomaterials 2020, 10, 898. https://doi.org/10.3390/nano10050898

AMA Style

Carbone C, Caddeo C, Grimaudo MA, Manno DE, Serra A, Musumeci T. Ferulic Acid-NLC with Lavandula Essential Oil: A Possible Strategy for Wound-Healing? Nanomaterials. 2020; 10(5):898. https://doi.org/10.3390/nano10050898

Chicago/Turabian Style

Carbone, Claudia, Carla Caddeo, Maria Aurora Grimaudo, Daniela Erminia Manno, Antonio Serra, and Teresa Musumeci. 2020. "Ferulic Acid-NLC with Lavandula Essential Oil: A Possible Strategy for Wound-Healing?" Nanomaterials 10, no. 5: 898. https://doi.org/10.3390/nano10050898

APA Style

Carbone, C., Caddeo, C., Grimaudo, M. A., Manno, D. E., Serra, A., & Musumeci, T. (2020). Ferulic Acid-NLC with Lavandula Essential Oil: A Possible Strategy for Wound-Healing? Nanomaterials, 10(5), 898. https://doi.org/10.3390/nano10050898

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