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Bottom-Up Self-Assembly Based on DNA Nanotechnology

by Xuehui Yan 1,†, Shujing Huang 1,†, Yong Wang 1, Yuanyuan Tang 1 and Ye Tian 1,2,3,*
1
College of Engineering and Applied Sciences, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing 210023, China
2
Shenzhen Research Institute of Nanjing University, Shenzhen 518000, China
3
Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nanomaterials 2020, 10(10), 2047; https://doi.org/10.3390/nano10102047
Received: 9 September 2020 / Revised: 9 October 2020 / Accepted: 12 October 2020 / Published: 16 October 2020
(This article belongs to the Special Issue The Application of DNA Nanotechnology)
Manipulating materials at the atomic scale is one of the goals of the development of chemistry and materials science, as it provides the possibility to customize material properties; however, it still remains a huge challenge. Using DNA self-assembly, materials can be controlled at the nano scale to achieve atomic- or nano-scaled fabrication. The programmability and addressability of DNA molecules can be applied to realize the self-assembly of materials from the bottom-up, which is called DNA nanotechnology. DNA nanotechnology does not focus on the biological functions of DNA molecules, but combines them into motifs, and then assembles these motifs to form ordered two-dimensional (2D) or three-dimensional (3D) lattices. These lattices can serve as general templates to regulate the assembly of guest materials. In this review, we introduce three typical DNA self-assembly strategies in this field and highlight the significant progress of each. We also review the application of DNA self-assembly and propose perspectives in this field. View Full-Text
Keywords: self-assembly; bottom-up; DNA tile; DNA brick; DNA origami; nanoparticles self-assembly; bottom-up; DNA tile; DNA brick; DNA origami; nanoparticles
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MDPI and ACS Style

Yan, X.; Huang, S.; Wang, Y.; Tang, Y.; Tian, Y. Bottom-Up Self-Assembly Based on DNA Nanotechnology. Nanomaterials 2020, 10, 2047.

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