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Article

Influence of Serum Vitamin D Level in the Response of Actinic Keratosis to Photodynamic Therapy with Methylaminolevulinate

1
Dermatology Service, Hospital Univ. del Henares, Coslada, 28822 Madrid, Spain
2
Pathology Service, Hospital Puerta de Hierro, Majadahonda, 28222 Madrid, Spain
3
Department of Cellular Biology, Universidad Autónoma de Madrid, 28049 Madrid, Spain
4
Medicine and Medical Specialties Department, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Universidad de Alcalá, 28034 Madrid, Spain
5
Dermatology Service, Hospital Univ. Miguel Servet, 50009 Zaragoza, Spain
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(2), 398; https://doi.org/10.3390/jcm9020398
Received: 16 December 2019 / Revised: 17 January 2020 / Accepted: 25 January 2020 / Published: 1 February 2020
(This article belongs to the Special Issue Current Advances on Non-Melanoma Skin Cancer)
In mouse models of squamous cell carcinoma, pre-treatment with calcitriol prior to photodynamic therapy with aminolevulinic acid (ALA) enhances tumor cell death. We have evaluated the association between vitamin D status and the response of actinic keratoses to photodynamic therapy with methylaminolevulinate. Twenty-five patients with actinic keratoses on the head received one session of photodynamic therapy with methylaminolevulinate. Biopsies were taken at baseline and six weeks after treatment. Immuno-histochemical staining was performed for VDR, P53, Ki67 and β-catenin. Basal serum 25(OH)D levels were determined. Cases with a positive histological response to treatment had significantly higher serum 25(OH)D levels (26.96 (SD 7.49) ngr/mL) than those without response (18.60 (SE 7.49) ngr/mL) (p = 0.05). Patients with a complete clinical response displayed lower basal VDR expression (35.71% (SD 19.88)) than partial responders (62.78% (SD 16.735)), (p = 0.002). Our results support a relationship between vitamin D status and the response of actinic keratoses to photodynamic therapy with methylaminolevulinate. View Full-Text
Keywords: photochemotherapy; methylaminolevulinate; actinic keratosis; vitamin d; calcitriol; vitamin d receptor photochemotherapy; methylaminolevulinate; actinic keratosis; vitamin d; calcitriol; vitamin d receptor
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MDPI and ACS Style

Moreno, R.; Nájera, L.; Mascaraque, M.; Juarranz, Á.; González, S.; Gilaberte, Y. Influence of Serum Vitamin D Level in the Response of Actinic Keratosis to Photodynamic Therapy with Methylaminolevulinate. J. Clin. Med. 2020, 9, 398. https://doi.org/10.3390/jcm9020398

AMA Style

Moreno R, Nájera L, Mascaraque M, Juarranz Á, González S, Gilaberte Y. Influence of Serum Vitamin D Level in the Response of Actinic Keratosis to Photodynamic Therapy with Methylaminolevulinate. Journal of Clinical Medicine. 2020; 9(2):398. https://doi.org/10.3390/jcm9020398

Chicago/Turabian Style

Moreno, Ricardo, Laura Nájera, Marta Mascaraque, Ángeles Juarranz, Salvador González, and Yolanda Gilaberte. 2020. "Influence of Serum Vitamin D Level in the Response of Actinic Keratosis to Photodynamic Therapy with Methylaminolevulinate" Journal of Clinical Medicine 9, no. 2: 398. https://doi.org/10.3390/jcm9020398

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