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“To Be Microbiocidal and Not to Be Cytotoxic at the Same Time…”—Silver Nanoparticles and Their Main Role on the Surface of Titanium Alloy Implants
Open AccessArticle

Electrospun Polyethylene Terephthalate Nanofibers Loaded with Silver Nanoparticles: Novel Approach in Anti-Infective Therapy

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Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 060042 Bucharest, Romania
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Academy of Romanian Scientists, 050094 Bucharest, Romania
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ICUB, Research Institute of Bucharest University, University of Bucharest, 030018 Bucharest, Romania
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Faculty of Engineering in Foreign Languages, University Politehnica of Bucharest, 060042 Bucharest, Romania
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Institute of Life Sciences, Vasile Goldis Western University of Arad, 310414 Arad, Romania
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Microbiology Immunology Department, Faculty of Biology, University of Bucharest, 050107 Bucharest, Romania
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Faculty of Medicine, Vasile Goldis Western University of Arad, 310045 Arad, Romania
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(7), 1039; https://doi.org/10.3390/jcm8071039
Received: 17 May 2019 / Revised: 4 July 2019 / Accepted: 7 July 2019 / Published: 16 July 2019
(This article belongs to the Special Issue Biomaterial-Related Infections)
Polyethylene terephthalate (PET) is a major pollutant polymer, due to its wide use in food packaging and fiber production industries worldwide. Currently, there is great interest for recycling the huge amount of PET-based materials, derived especially from the food and textile industries. In this study, we applied the electrospinning technique to obtain nanostructured fibrillary membranes based on PET materials. Subsequently, the recycled PET networks were decorated with silver nanoparticles through the chemical reduction method for antimicrobial applications. After the characterization of the materials in terms of crystallinity, chemical bonding, and morphology, the effect against Gram-positive and Gram-negative bacteria, as well as fungal strains, was investigated. Furthermore, in vitro and in vivo biocompatibility tests were performed in order to open up potential biomedical applications, such as wound dressings or implant coatings. Silver-decorated fibers showed lower cytotoxicity and inflammatory effects and increased antibiofilm activity, thus highlighting the potential of these systems for antimicrobial purposes. View Full-Text
Keywords: polyethylene terephthalate; PET; silver nanoparticles; electrospinning; nanofibers; antimicrobial agents; biocompatibility polyethylene terephthalate; PET; silver nanoparticles; electrospinning; nanofibers; antimicrobial agents; biocompatibility
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Grumezescu, A.M.; Stoica, A.E.; Dima-Bălcescu, M.-Ș.; Chircov, C.; Gharbia, S.; Baltă, C.; Roșu, M.; Herman, H.; Holban, A.M.; Ficai, A.; Vasile, B.S.; Andronescu, E.; Chifiriuc, M.C.; Hermenean, A. Electrospun Polyethylene Terephthalate Nanofibers Loaded with Silver Nanoparticles: Novel Approach in Anti-Infective Therapy. J. Clin. Med. 2019, 8, 1039.

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