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The Beneficial Effect of Acute Exercise on Motor Memory Consolidation is Modulated by Dopaminergic Gene Profile

1
Department of Nutrition, Exercise and Sports, University of Copenhagen, 2200 Copenhagen, Denmark
2
Department of Neuroscience, University of Copenhagen, 2200 Copenhagen, Denmark
3
Copenhagen Centre for Team Sport and Health, University of Copenhagen, 2200 Copenhagen, Denmark
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Department of Forensic Medicine, University of Copenhagen, 2200 Copenhagen, Denmark
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Faculty of Kinesiology and Health Studies, University of Regina, Regina, SA S4S 0A2, Canada
6
School of Physical and Occupational Therapy, McGill University, Montreal, QC H3G 1Y5, Canada
7
Memory and Motor Rehabilitation Laboratory (MEMORY-LAB), Feil and Oberfield Research Centre, Jewish Rehabilitation Hospital, Montreal Centre for Interdisciplinary Research in Rehabilitation (CRIR), Laval, QC H7M 3L9, Canada
*
Authors to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(5), 578; https://doi.org/10.3390/jcm8050578
Received: 4 March 2019 / Revised: 21 April 2019 / Accepted: 22 April 2019 / Published: 27 April 2019
(This article belongs to the Special Issue The Effects of Exercise on Cognitive Function)
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Abstract

When aerobic exercise is performed following skilled motor practice, it can enhance motor memory consolidation. Previous studies have suggested that dopamine may play a role in motor memory consolidation, but whether it is involved in the exercise effects on consolidation is unknown. Hence, we aimed to investigate the influence of dopaminergic pathways on the exercise-induced modulation of motor memory consolidation. We compared the effect of acute exercise on motor memory consolidation between the genotypes that are known to affect dopaminergic transmission and learning. By combining cluster analyses and fitting linear models with and without included polymorphisms, we provide preliminary evidence that exercise benefits the carriers of alleles that are associated with low synaptic dopamine content. In line with previous reports, our findings implicate dopamine as a modulator of the exercise-induced effects on motor memory consolidation, and suggest exercise as a potential clinical tool to counteract low endogenous dopamine bioavailability. Further experiments are needed to establish causal relations. View Full-Text
Keywords: physical activity; consolidation; dopamine; genetics; motor learning; single-nucleotide polymorphisms; dopamine receptor physical activity; consolidation; dopamine; genetics; motor learning; single-nucleotide polymorphisms; dopamine receptor
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Christiansen, L.; Thomas, R.; Beck, M.M.; Pingel, J.; Andersen, J.D.; Mang, C.S.; Madsen, M.A.J.; Roig, M.; Lundbye-Jensen, J. The Beneficial Effect of Acute Exercise on Motor Memory Consolidation is Modulated by Dopaminergic Gene Profile. J. Clin. Med. 2019, 8, 578.

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