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Beneficial Effect of Exercise on Cognitive Function during Peripheral Arterial Disease: Potential Involvement of Myokines and Microglial Anti-Inflammatory Phenotype Enhancement

1
Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Avenida Brasil 4365, Rio de Janeiro 21040-360, Brazil
2
Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Faculté de Médecine, Equipe d’Accueil 3072, 11 Rue Humann, 67000 Strasbourg, France
3
Service de Chirurgie Cardiovasculaire, Pôle de Pathologie Cardiaque, Hôpitaux Universitaires, CHRU Strasbourg, 67000 CEDEX, France
4
Service de Physiologie et d’explorations Fonctionnelles, Hôpitaux Universitaires de Strasbourg, Nouvel Hôpital Civil, 1 place de l’Hôpital, 67091 Strasbourg CEDEX, France
5
Instituto Nacional de Cardiologia, Ministério da Saúde, Rua das lanjeiras 374, Rio de Janeiro 22240-006, Brazil
6
Service de Médecine Interne, Diabète et Maladies Métaboliques, Pôle M.I.R.N.E.D., Hôpitaux Universitaires, CHRU Strasbourg, 67000 CEDEX, France
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(5), 653; https://doi.org/10.3390/jcm8050653
Received: 5 March 2019 / Revised: 5 April 2019 / Accepted: 7 May 2019 / Published: 10 May 2019
(This article belongs to the Special Issue The Effects of Exercise on Cognitive Function)
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Abstract

Peripheral arterial disease (PAD), leading to intermittent claudication, critical ischemia with rest pain, and/or tissue damage, is a public health issue associated with significant morbidity and mortality. Little is known about the link between PAD, cognitive function, and whether exercise might reduce cognitive dysfunction in PAD patients, as previously observed concerning both quality of life and prognosis. This review highlights the fact that patients suffering from PAD often demonstrate cognitive dysfunction characterized by reduced performance in nonverbal reasoning, reduced verbal fluency, and decreased information processing speed and a greater risk for progression toward dementia. Further, the data presented support that physical exercise, likely through myokine secretion and microglial anti-inflammatory phenotype enhancement, might participate in the cognition protection in common clinical settings. View Full-Text
Keywords: peripheral arterial disease; ankle-brachial index; cognitive dysfunction; brain; exercise; myokines; microglia; BDNF; cathepsin-B; irisin peripheral arterial disease; ankle-brachial index; cognitive dysfunction; brain; exercise; myokines; microglia; BDNF; cathepsin-B; irisin
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    Description: Table 1: Cognitive function in PAD patients
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MDPI and ACS Style

Leardini-Tristao, M.; Charles, A.-L.; Lejay, A.; Pizzimenti, M.; Meyer, A.; Estato, V.; Tibiriçá, E.; Andres, E.; Geny, B. Beneficial Effect of Exercise on Cognitive Function during Peripheral Arterial Disease: Potential Involvement of Myokines and Microglial Anti-Inflammatory Phenotype Enhancement. J. Clin. Med. 2019, 8, 653.

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