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J. Clin. Med. 2019, 8(2), 151;

Predictive Factors of Efficacy Maintenance after Testosterone Treatment Cessation

Department of Urology, Men’s Health Clinic, Inje University, Seoul Paik Hospital, Seoul 04551, Korea
Department of Urology, Inje University, Seoul Paik Hospital, Seoul 04551, Korea
Department of Clinical Laboratory Science, Daejeon Health Institute of Technology, Daejeon 34504, Korea
Department of Urology, National Medical Center, Seoul 04564, Korea
Department of Urology, Korea University, Guro Hospital, Seoul 08308, Korea
Author to whom correspondence should be addressed.
Received: 6 January 2019 / Revised: 17 January 2019 / Accepted: 28 January 2019 / Published: 29 January 2019
(This article belongs to the Special Issue Testosterone and Men’s Health: From Evidence to Clinical Practice)
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There is no conclusive evidence as to whether patients with testosterone deficiency (TD) who benefit from testosterone treatment (TRT) must continue the treatment for the rest of their lives. In some patients, the effect of TRT does not maintained after stopping TRT and, some patients show no significant TD symptoms, with normal testosterone levels after TRT cessation. Therefore, we investigated the predictive factors of response maintenance after TRT cessation. A total of 151 men with TD who responded to TRT were followed up for six months after TRT discontinuation. Ninety-two patients (Group I) failed to show response maintenance; 59 patients (Group II) had a maintained response. The groups did not differ in baseline characteristics or the type of TRT (oral, gel, short/long-acting injectables). However, TRT duration was significantly longer (10.7 vs. 5.2 months), and peak total testosterone (TT) level was significantly higher (713.7 vs. 546.1 ng/dL), in Group II than in Group I. More patients regularly exercised in Group II than in Group I (45.8% vs. 9.8%, p < 0.001). A multivariate logistic regression analysis revealed that exercise (B = 2.325, odds ratio = 10.231, p < 0.001) and TRT duration (B = 0.153, Exp(B) = 1.166, p < 0.001) were independent predictive factors of response maintenance. In men with TD who respond to TRT, longer treatment periods can improve the response durability after TRT cessation, regardless of the type of TRT. Additionally, regular exercise can increase the probability of maintaining the response after TRT cessation. View Full-Text
Keywords: testosterone; testosterone deficiency; testosterone replacement therapy; response maintenance testosterone; testosterone deficiency; testosterone replacement therapy; response maintenance

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Park, M.G.; Yeo, J.K.; Park, S.G.; Na, W.; Moon, D.G. Predictive Factors of Efficacy Maintenance after Testosterone Treatment Cessation. J. Clin. Med. 2019, 8, 151.

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