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Article

Anemia and Iron Deficiency in Children with Chronic Kidney Disease (CKD): Data from the Know-Ped CKD Study

1
Department of Pediatrics, Yonsei University College of Medicine, Yonsei-ro 50, Seodaemun-gu, C.P.O. Box 8044, Seoul 03722, Korea
2
Division of Pediatric Nephrology, Severance Children’s Hospital, Seoul 03722, Korea
3
Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital, Seoul 07441, Korea
4
Department of Pediatrics, Seoul National University Children’s Hospital & Seoul National University College of Medicine, Seoul 03080, Korea
5
Department of Pediatrics, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, 88, Olympic-ro 43-Gil, Songpa-Gu, Seoul 05505, Korea
6
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea
7
Department of Pediatrics, Jeju National University School of Medicine, Jeju 63241, Korea
8
Department of Pediatrics, Pusan National University Children’s Hospital, Yangsan 50612, Korea
9
Department of Pediatrics, Kyungpook National University, School of Medicine, Daegu 41404, Korea
10
Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul 03722, Korea
*
Authors to whom correspondence should be addressed.
These authors are contributed equally to this work.
These authors are contributed equally to this work.
J. Clin. Med. 2019, 8(2), 152; https://doi.org/10.3390/jcm8020152
Received: 5 December 2018 / Revised: 14 January 2019 / Accepted: 15 January 2019 / Published: 29 January 2019
Children with chronic kidney disease (CKD) are at high risk of anemia, an important risk factor for cardiovascular disease and poor quality of life. The present study used baseline data from the Korean cohort study for Outcome in patients With Pediatric Chronic Kidney Disease (KNOW-PedCKD). A Total of 437 patients was included in the analyses excluding missing data. The characteristics of patients with and without anemia and those of patients with and without iron deficiency were compared. Logistic regression analysis and Pearson correlation were conducted to evaluate associated risk factors and correlations in children with CKD. Anemia in children with CKD was associated with older age, low body weight and body mass index (BMI) z-score, birth age, preceding glomerulonephritis, decreased estimated glomerular filtration rate (eGFR), low levels of serum albumin and calcium, high levels of serum intact parathyroid hormone (iPTH), and serum phosphorus. Anemia was correlated positively with changes in the BMI z-score, body weight, and serum albumin and cholesterol levels, but correlated negatively with serum calcium, iPTH, ferritin levels, and transferrin saturation. Iron deficiency in children with CKD was associated with young age, low hemoglobin and serum ferritin levels, high BMI z-scores, and low levels of serum iPTH. This is the first nationwide cohort study of anemia in Korean children with CKD and the first prospective pediatric CKD cohort study in Asia. The study results demonstrated that anemia and iron deficiency are affected by various factors, including age, BMI, and levels of serum iPTH. To improve the retrospective outcome of affected children, it is important to understand the effect of each of these factors and to attempt an early intervention to prevent anemia and iron deficiency by regular measurement of these parameters in children at risk. View Full-Text
Keywords: anemia; iron deficiency; chronic kidney disease anemia; iron deficiency; chronic kidney disease
MDPI and ACS Style

Lee, K.H.; Park, E.; Choi, H.J.; Kang, H.G.; Ha, I.-S.; Cheong, H.I.; Park, Y.S.; Cho, H.; Han, K.H.; Kim, S.H.; Cho, M.H.; Lee, J.H.; Shin, J.I. Anemia and Iron Deficiency in Children with Chronic Kidney Disease (CKD): Data from the Know-Ped CKD Study. J. Clin. Med. 2019, 8, 152. https://doi.org/10.3390/jcm8020152

AMA Style

Lee KH, Park E, Choi HJ, Kang HG, Ha I-S, Cheong HI, Park YS, Cho H, Han KH, Kim SH, Cho MH, Lee JH, Shin JI. Anemia and Iron Deficiency in Children with Chronic Kidney Disease (CKD): Data from the Know-Ped CKD Study. Journal of Clinical Medicine. 2019; 8(2):152. https://doi.org/10.3390/jcm8020152

Chicago/Turabian Style

Lee, Keum H., Eujin Park, Hyun J. Choi, Hee G. Kang, Il-Soo Ha, Hae I. Cheong, Young S. Park, Heeyeon Cho, Kyoung H. Han, Seong H. Kim, Min H. Cho, Joo H. Lee, and Jae I. Shin 2019. "Anemia and Iron Deficiency in Children with Chronic Kidney Disease (CKD): Data from the Know-Ped CKD Study" Journal of Clinical Medicine 8, no. 2: 152. https://doi.org/10.3390/jcm8020152

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