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J. Clin. Med. 2019, 8(2), 209; https://doi.org/10.3390/jcm8020209

The Optimal Indication for Testosterone Replacement Therapy in Late Onset Hypogonadism

1,2,3,4
and
1,2,3,4,*
1
Department of Urology, Chonbuk National University Medical School, Jeonju 54907, Korea
2
Research Institute of Clinical Medicine, Chonbuk National University, Jeonju 54907, Korea
3
Biomedical Research Institute, Chonbuk National University Hospital, Jeonju 54907, Korea
4
Clinical Trial Center of Medical Device, Chonbuk National University Hospital, Jeonju 54907, Korea
*
Author to whom correspondence should be addressed.
Received: 2 January 2019 / Revised: 1 February 2019 / Accepted: 3 February 2019 / Published: 7 February 2019
(This article belongs to the Special Issue Testosterone and Men’s Health: From Evidence to Clinical Practice)
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Abstract

The use of testosterone replacement therapy (TRT) for late-onset hypogonadism (LOH) is increasing every year; however, the literature shows that many men are using testosterone (T) without a clear indication. Previous studies have estimated that up to 25% of men who receive TRT do not have their T tested prior to initiation of the therapy. Given the growing concern and need for proper TRT, clinicians need evidence-based information that informs them on the optimal indication for TRT in LOH patients. The diagnosis of LOH requires the presence of characteristic signs and symptoms, in combination with decreased serum total testosterone (TT). Based on the recent guidelines by the International Society for the Study of Aging Male (ISSAM), the European Association of Urology (EAU), the European Society of Endocrinology (ESE), the European Academy of Andrology (EAA), and the American Association of Urology (AUA), a TT of 250–350 ng/dL is the proper threshold value to define low T. The optimal indication for TRT in LOH is the presence of signs and symptoms of hypogonadism, and low T without contraindications for TRT. View Full-Text
Keywords: indication; hypogonadism; testosterone indication; hypogonadism; testosterone
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Shin, Y.S.; Park, J.K. The Optimal Indication for Testosterone Replacement Therapy in Late Onset Hypogonadism. J. Clin. Med. 2019, 8, 209.

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