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Article

A New Antibacterial Agent-Releasing Polydimethylsiloxane Coating for Polymethyl Methacrylate Dental Restorations

1
Department of Prosthodontics, School of Dentistry, Institute for Translational Research in Dentistry, Kyungpook National University, Daegu 41940, Korea
2
Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Korea
3
Department of Polymer Science and Engineering, Kyungpook National University, Daegu 41566, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
J. Clin. Med. 2019, 8(11), 1831; https://doi.org/10.3390/jcm8111831
Received: 20 September 2019 / Revised: 29 October 2019 / Accepted: 29 October 2019 / Published: 1 November 2019
Chlorhexidine (CHX) has been incorporated into the composition of polymethyl methacrylate (PMMA) dental restorations to enhance their antimicrobial performance. However, the controlled delivery of CHX remains a challenge. Although previous findings with pure silica or polymer coatings demonstrated the resistance to bacterial adhesion, they did not provide antibacterial activity beyond the coated surface. Polydimethylsiloxane (PDMS) and mesoporous silica nanoparticles (MSNs) are widely used in biomedical science as a transfer medium in drug delivery systems. Here, the MSNs are used to encapsulate CHX, and the combination is added to PDMS. A thin coating film is formed on the PMMA, using oxygen plasma and thermal treatment. The liquid chromatography analysis shows that the coating film has high encapsulation efficiency and loading capacity, with a slow and stable release rate of CHX. The cytotoxicity tests also show that the coating does not affect the proinflammatory cytokines, cellular mitotic activity, or apoptotic cell death. The ability of the coating to release CHX indicates that the coating may even be effective against bacteria that are not directly in contact with the surface. This antibacterial protective film is expected to be a novel method to inhibit bacterial activity distal to the coated surfaces of PMMA restorations. View Full-Text
Keywords: polydimethylsiloxane; chlorhexidine; mesoporous silica nanoparticles; antibacterial coating; polymethyl methacrylate polydimethylsiloxane; chlorhexidine; mesoporous silica nanoparticles; antibacterial coating; polymethyl methacrylate
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MDPI and ACS Style

Mai, H.-N.; Kim, D.-Y.; Hyun, D.C.; Park, J.H.; Lee, S.M.; Lee, D.-H. A New Antibacterial Agent-Releasing Polydimethylsiloxane Coating for Polymethyl Methacrylate Dental Restorations. J. Clin. Med. 2019, 8, 1831. https://doi.org/10.3390/jcm8111831

AMA Style

Mai H-N, Kim D-Y, Hyun DC, Park JH, Lee SM, Lee D-H. A New Antibacterial Agent-Releasing Polydimethylsiloxane Coating for Polymethyl Methacrylate Dental Restorations. Journal of Clinical Medicine. 2019; 8(11):1831. https://doi.org/10.3390/jcm8111831

Chicago/Turabian Style

Mai, Hang-Nga, Do-Yeon Kim, Dong Choon Hyun, Ju Hayng Park, Sang Min Lee, and Du-Hyeong Lee. 2019. "A New Antibacterial Agent-Releasing Polydimethylsiloxane Coating for Polymethyl Methacrylate Dental Restorations" Journal of Clinical Medicine 8, no. 11: 1831. https://doi.org/10.3390/jcm8111831

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