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Article

Increased Circulating VAP-1 Levels Are Associated with Liver Fibrosis in Chronic Hepatitis C Infection

1
Department of Internal Medicine II, Saarland University Medical Center, 66421 Homburg, Germany
2
Laboratory of Metabolic Liver Diseases, Centre for Preclinical Research, Department of General, Transplant and Liver Surgery, Medical University of Warsaw, 02-097 Warsaw, Poland
3
Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, L-4367 Belvaux, Luxembourg
4
Department of Gastroenterology and Oncology, Rhein-Kreis-Neuss Hospital, 41515 Grevenbroich, Germany
5
Centre Hospitalier Emile Mayrisch, L-4240 Esch-sur-Alzette, Luxembourg
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(1), 103; https://doi.org/10.3390/jcm8010103
Received: 25 November 2018 / Revised: 7 January 2019 / Accepted: 9 January 2019 / Published: 17 January 2019
(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Vascular adhesion protein-1 (VAP-1) is a multifunction protein. While membrane-bound VAP-1 is an adhesion protein, soluble VAP-1 catalyzes the deamination of primary amines through its semicarbazide-sensitive amino oxidase (SSAO) activity. VAP-1 supports the transmigration of leukocytes and increases oxidative stress. In chronic liver diseases, it plays a role in leukocyte infiltration and fibrogenesis. Here, we measured VAP-1 plasma concentration and its SSAO activity in 322 patients with chronic hepatitis C infection and evaluated the association of VAP-1 with fibrosis stages. VAP-1 concentration strongly correlated with liver stiffness and was the second strongest influencing variable after gamma-glutamytransferase (GGT) for liver stiffness in regression analysis. The VAP-1 concentration increased with advancing fibrosis stages and the highest concentrations were found in patients with cirrhosis. According to the receiver operating characteristic (ROC) analysis, a VAP-1 cut-off value of 541 ng/mL predicted histologically confirmed cirrhosis (sensitivity 74%; specificity 72%). SSAO activity correlated only moderately with liver stiffness, showing a relatively small increase in advanced fibrosis. To our knowledge, this is the first study on VAP-1 in chronic hepatitis C infection showing its association with progressive fibrosis. In conclusion, VAP-1 plasma concentration, rather than its SSAO activity, may represent a non-invasive biomarker for monitoring fibrogenesis in patients with chronic hepatitis C infection. View Full-Text
Keywords: VAP-1; vascular adhesion protein 1; SSAO activity; semicarbazide-sensitive amino oxidase; chronic liver diseases; fibrosis; liver stiffness; Fibroscan; HCV VAP-1; vascular adhesion protein 1; SSAO activity; semicarbazide-sensitive amino oxidase; chronic liver diseases; fibrosis; liver stiffness; Fibroscan; HCV
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MDPI and ACS Style

Kraemer, M.; Krawczyk, M.; Noor, F.; Grünhage, F.; Lammert, F.; Schneider, J.G. Increased Circulating VAP-1 Levels Are Associated with Liver Fibrosis in Chronic Hepatitis C Infection. J. Clin. Med. 2019, 8, 103. https://doi.org/10.3390/jcm8010103

AMA Style

Kraemer M, Krawczyk M, Noor F, Grünhage F, Lammert F, Schneider JG. Increased Circulating VAP-1 Levels Are Associated with Liver Fibrosis in Chronic Hepatitis C Infection. Journal of Clinical Medicine. 2019; 8(1):103. https://doi.org/10.3390/jcm8010103

Chicago/Turabian Style

Kraemer, Marcel, Marcin Krawczyk, Fozia Noor, Frank Grünhage, Frank Lammert, and Jochen G. Schneider. 2019. "Increased Circulating VAP-1 Levels Are Associated with Liver Fibrosis in Chronic Hepatitis C Infection" Journal of Clinical Medicine 8, no. 1: 103. https://doi.org/10.3390/jcm8010103

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