Feasibility and Impact of Left Atrial Appendage Closure in Patients with Cardiac Implantable Electronic Devices: Insights from a Prospective Registry
, Sven Ledwoch 1, Roberto Galea 1, Antanas Gasys 1, Marco Gamardella 1, George C. M. Siontis 1, Lorenz Räber 1 and Laurent Roten 1,*Round 1
Reviewer 1 Report
Comments and Suggestions for AuthorsPlease read the attachment. Thank you.
Comments for author File: 
Comments.pdf
Author Response
Please find my response to reviewer in the attached file
Author Response File: Author Response.pdf
Reviewer 2 Report
Comments and Suggestions for AuthorsAs the authors have acknowledged, this study is underpowered and retrospective, lacks a control group. No significant conclusions could be drawn about atrial fib progression due to lack of controls. Lead dislodgement was not recorded, the duration or length of leads in place was not mentioned (older leads are harder to dislodge). Prospective studies or larger data sets would be helpful to assess these same clinical questions.
Author Response
We agree, our study have several limitations and potential bias cannot be excluded. Therefore, we stated that larger, prospective studies are warranted to confirm our findings.
