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Article

Feasibility of Outpatient Stem Cell Transplantation in Multiple Myeloma and Risk Factors Predictive of Hospital Admission

by
Kristin Larsen
1,
Horace Spencer
2,
Meera Mohan
3,
Clyde Bailey
1,
Kerri Hill
1,
Mathew Kottarathara
1,
Richa Parikh
1,
Shadiqul Hoque
1,
Amani Erra
1,
Angel A. Mitma
1,
Pankaj Mathur
1,
Lakshmi Yarlagadda
1,
Sravani Gundarlapalli
1,
Yetunde Ogunsesan
1,
Munawwar Hussain
1,
Nishanth Thalambedu
1,
Jaskirat Sethi
1,
Samer Al Hadidi
1,
Sharmilan Thanendrarajan
1,
Monica Graziutti
1,
Maurizio Zangari
1,
Bart Barlogie
1,
Frits van Rhee
1,
Guido Tricot
1 and
Carolina Schinke
1,*add Show full author list remove Hide full author list
1
Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
2
Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
3
Medical College of Wisconsin Cancer Center, Froedtert Hospital, Milwaukee, WI 53226, USA
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2022, 11(6), 1640; https://doi.org/10.3390/jcm11061640
Submission received: 6 January 2022 / Revised: 9 March 2022 / Accepted: 11 March 2022 / Published: 16 March 2022
(This article belongs to the Special Issue Hematopoietic Stem Cell Transplantation: Current Status and Future Research)
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Abstract

High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) remains the standard of care for multiple myeloma (MM) patients. Although outpatient ASCT has been shown to be safe and feasible, the procedure is overall rare with most patients in the US undergoing inpatient ASCT. Furthermore, hospitalization rates for patients that undergo outpatient ASCT remain high. Adequate markers that predict hospitalization during outpatient ASCT are lacking, yet would be of great clinical value to select patients that are suited to outpatient ASCT. In this study we aimed to elucidate differences between planned outpatient and inpatient ASCT and further evaluated clinical characteristics that are significantly associated with hospitalization during planned outpatient hospitalization. Factors that were significantly associated with a planned inpatient ASCT included an advanced MM disease stage, worse performance status as well as non-Caucasian race, while low albumin levels and female gender were significantly associated with hospitalization during outpatient ASCT. The results of this analysis provide crucial knowledge of factors that are associated with planned inpatient ASCT and hospitalization during outpatient ASCT and could guide the treating physician in decision-making and further facilitate outpatient transplantation.
Keywords: multiple myeloma; autologous stem cell transplantation; hospitalization multiple myeloma; autologous stem cell transplantation; hospitalization

Share and Cite

MDPI and ACS Style

Larsen, K.; Spencer, H.; Mohan, M.; Bailey, C.; Hill, K.; Kottarathara, M.; Parikh, R.; Hoque, S.; Erra, A.; Mitma, A.A.; et al. Feasibility of Outpatient Stem Cell Transplantation in Multiple Myeloma and Risk Factors Predictive of Hospital Admission. J. Clin. Med. 2022, 11, 1640. https://doi.org/10.3390/jcm11061640

AMA Style

Larsen K, Spencer H, Mohan M, Bailey C, Hill K, Kottarathara M, Parikh R, Hoque S, Erra A, Mitma AA, et al. Feasibility of Outpatient Stem Cell Transplantation in Multiple Myeloma and Risk Factors Predictive of Hospital Admission. Journal of Clinical Medicine. 2022; 11(6):1640. https://doi.org/10.3390/jcm11061640

Chicago/Turabian Style

Larsen, Kristin, Horace Spencer, Meera Mohan, Clyde Bailey, Kerri Hill, Mathew Kottarathara, Richa Parikh, Shadiqul Hoque, Amani Erra, Angel A. Mitma, and et al. 2022. "Feasibility of Outpatient Stem Cell Transplantation in Multiple Myeloma and Risk Factors Predictive of Hospital Admission" Journal of Clinical Medicine 11, no. 6: 1640. https://doi.org/10.3390/jcm11061640

APA Style

Larsen, K., Spencer, H., Mohan, M., Bailey, C., Hill, K., Kottarathara, M., Parikh, R., Hoque, S., Erra, A., Mitma, A. A., Mathur, P., Yarlagadda, L., Gundarlapalli, S., Ogunsesan, Y., Hussain, M., Thalambedu, N., Sethi, J., Al Hadidi, S., Thanendrarajan, S., ... Schinke, C. (2022). Feasibility of Outpatient Stem Cell Transplantation in Multiple Myeloma and Risk Factors Predictive of Hospital Admission. Journal of Clinical Medicine, 11(6), 1640. https://doi.org/10.3390/jcm11061640

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