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Tumor-Associated Granulomas Preceding a Diagnosis of Thoracic Sarcoidosis: A Retrospective, Single-Center Cohort Study

1
Department of Pathology, University Hospital La Princesa, Diego de León, 62, 28006 Madrid, Spain
2
Department of Pneumology, University Hospital La Princesa, Diego de León, 62, 28006 Madrid, Spain
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Department of Radiology, University Hospital La Princesa, Diego de León, 62, 28006 Madrid, Spain
4
Department of Radiology, University Hospital La Moraleja, Avda. Francisco Pi y Margall, 81, 28050 Madrid, Spain
*
Author to whom correspondence should be addressed.
Academic Editors: Valérie Besnard and Makoto Miyara
J. Clin. Med. 2021, 10(18), 4151; https://doi.org/10.3390/jcm10184151
Received: 10 July 2021 / Revised: 8 September 2021 / Accepted: 12 September 2021 / Published: 15 September 2021
There is a relationship between systemic sarcoidosis (SS) and malignancy. Sarcoidosis results from an exaggerated immune response in genetically susceptible individuals. In oncologic patients with sarcoidosis, tumoral antigens and antineoplastic treatment are considered potential triggering factors. The observation of a patient with granulomas in a parotid carcinoma who later developed SS led us to review the previous tumors of patients with SS. The aim of the study is to see whether granulomas were already present in the tumors that preceded sarcoidosis. We identified 196 sarcoidosis patients, 47 of whom had previously had a tumor. We were able to review 29 cases, 12 of which showed tumor-associated granulomas (TAGs) (41.4%). This ratio is much higher than that of the normal population (4.4–13.8). We analyzed five control patients without sarcoidosis for each tumor. In conclusion, we observed an increased number of TAGs in patients who later developed SS. This finding reinforces a pathogenic relationship between SS and neoplasia. The histology of tumors in patients with SS should be reviewed in an attempt to identify granulomas. View Full-Text
Keywords: granulomas; neoantigens; neoplasia; sarcoidosis; sarcoid-like reaction; tumoral antigens granulomas; neoantigens; neoplasia; sarcoidosis; sarcoid-like reaction; tumoral antigens
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MDPI and ACS Style

Muñoz-Hernández, P.; Valdivia-Mazeyra, M.; Ancochea, J.; Alonso Pérez, T.; Rajas, O.; Valenzuela, C.; Hernández-Muñiz, S.; Esteban-Peris, A.; Jiménez-Heffernan, J.A. Tumor-Associated Granulomas Preceding a Diagnosis of Thoracic Sarcoidosis: A Retrospective, Single-Center Cohort Study. J. Clin. Med. 2021, 10, 4151. https://doi.org/10.3390/jcm10184151

AMA Style

Muñoz-Hernández P, Valdivia-Mazeyra M, Ancochea J, Alonso Pérez T, Rajas O, Valenzuela C, Hernández-Muñiz S, Esteban-Peris A, Jiménez-Heffernan JA. Tumor-Associated Granulomas Preceding a Diagnosis of Thoracic Sarcoidosis: A Retrospective, Single-Center Cohort Study. Journal of Clinical Medicine. 2021; 10(18):4151. https://doi.org/10.3390/jcm10184151

Chicago/Turabian Style

Muñoz-Hernández, Patricia, Mariel Valdivia-Mazeyra, Julio Ancochea, Tamara Alonso Pérez, Olga Rajas, Claudia Valenzuela, Susana Hernández-Muñiz, Amparo Esteban-Peris, and José A. Jiménez-Heffernan 2021. "Tumor-Associated Granulomas Preceding a Diagnosis of Thoracic Sarcoidosis: A Retrospective, Single-Center Cohort Study" Journal of Clinical Medicine 10, no. 18: 4151. https://doi.org/10.3390/jcm10184151

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