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Article

Assessment of EULAR/ACR-2019, SLICC-2012 and ACR-1997 Classification Criteria in SLE with Longstanding Disease

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Department of Rheumatology, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain
2
Sant Pau Biomedical Research Institute (IIB Sant Pau), 08025 Barcelona, Spain
3
Department of Immunology, Universitat Autònoma de Barcelona (UAB), 08193 Barcelona, Spain
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CIBER Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
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Department of Clinical Epidemiology and Public Health, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain
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Department of Immunology, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Matteo Piga
J. Clin. Med. 2021, 10(11), 2377; https://doi.org/10.3390/jcm10112377
Received: 31 March 2021 / Revised: 24 May 2021 / Accepted: 25 May 2021 / Published: 28 May 2021
(This article belongs to the Special Issue Systemic Lupus Erythematosus: Pathogenesis, Diagnosis and Treatment)
Background: Different classification criteria for systemic lupus erythematosus (SLE) have been launched over the years. Our aim was to evaluate the performance of the EULAR/ACR-2019, SLICC-2012 and ACR-1997 classification criteria in a cohort of SLE patients with longstanding disease. Methods: Descriptive observational study in 79 patients with established and longstanding SLE. The three classification criteria sets were applied to those patients. Results: Of the 79 patients, 70 were women (88.6%), with a mean age of 51.8 ± 14 years and a mean disease duration of 15.2 ± 11.5 years. The sensitivity of the different criteria were: 51.9%, 87.3% and 86.1% for ACR-1997, SLICC-2012 and EULAR/ACR-2019, respectively. In total, 68 out of 79 patients (53.7%) met all three classification criteria; 11.4% did not meet any classification criteria and were characterized by low SLEDAI (0.6 ± 0.9), low SLICC/ACR Damage Index (0.88 ± 0.56) and fulfilling only skin domains, antiphospholipid antibodies or hypocomplementemia. To fulfill EULAR/ACR-2019 criteria was associated with low complement levels (p < 0.04), high anti-dsDNA levels (p < 0.001), presence of lupus nephritis III-IV (p < 0.05) and arthritis (p < 0.001). Conclusion: The EULAR/ACR-2019 classification criteria showed high sensitivity, similar to SLICC-2012, in SLE patients with longstanding disease. Patients with serological, articular or renal involvement are more likely to fulfill SLICC-2012 or EULAR/ACR-2019 criteria. View Full-Text
Keywords: SLE; classification criteria; EULAR/ACR-2019; SLICC-2012; ACR-1997; longstanding lupus SLE; classification criteria; EULAR/ACR-2019; SLICC-2012; ACR-1997; longstanding lupus
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MDPI and ACS Style

Magallares, B.; Lobo-Prat, D.; Castellví, I.; Moya, P.; Gich, I.; Martinez-Martinez, L.; Park, H.; Millán, A.M.; Laiz, A.; Díaz-Torné, C.; Fernandez, S.; Corominas, H. Assessment of EULAR/ACR-2019, SLICC-2012 and ACR-1997 Classification Criteria in SLE with Longstanding Disease. J. Clin. Med. 2021, 10, 2377. https://doi.org/10.3390/jcm10112377

AMA Style

Magallares B, Lobo-Prat D, Castellví I, Moya P, Gich I, Martinez-Martinez L, Park H, Millán AM, Laiz A, Díaz-Torné C, Fernandez S, Corominas H. Assessment of EULAR/ACR-2019, SLICC-2012 and ACR-1997 Classification Criteria in SLE with Longstanding Disease. Journal of Clinical Medicine. 2021; 10(11):2377. https://doi.org/10.3390/jcm10112377

Chicago/Turabian Style

Magallares, Berta, David Lobo-Prat, Ivan Castellví, Patricia Moya, Ignasi Gich, Laura Martinez-Martinez, Hye Park, Ana M. Millán, Ana Laiz, César Díaz-Torné, Susana Fernandez, and Hèctor Corominas. 2021. "Assessment of EULAR/ACR-2019, SLICC-2012 and ACR-1997 Classification Criteria in SLE with Longstanding Disease" Journal of Clinical Medicine 10, no. 11: 2377. https://doi.org/10.3390/jcm10112377

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