Sudden Sensorineural Hearing Loss after COVID-19 Vaccination: A Review of the Available Evidence through the Prism of Causality Assessment
Abstract
1. Available Epidemiological Data on Sudden Sensorineural Hearing Loss
2. What Do We Currently Know about SSNHL Observed after mRNA COVID-19 Vaccination?
3. Quantification of Sudden Sensorineural Hearing Loss after COVID-19 Vaccination
4. Evaluation of Hearing Recovery in SSNHL Post-COVID-19 Vaccination: Benefits of Active Audiogram-Based Surveillance
5. When an Adverse Event Becomes an Adverse Effect and Then a Signal
6. Two Different but Complementary Approaches to Safety Signal Evaluation
7. Rare Vaccine Adverse Events: Challenges and Perspectives
Author Contributions
Funding
Conflicts of Interest
References
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Siegel’s Grade of Hearing Loss | Hearing Loss Degree (dB HL) |
---|---|
Grade 1 | ≤25 |
Grade 2 | 26–40 |
Grade 3 | 41–70 |
Grade 4 | 71–90 |
Grade 5 | >90 |
Number of SSNHL Cases after mRNA COVID-19 Vaccination = 171 (From January 2021 to February 2022, in France) | ||||||
---|---|---|---|---|---|---|
Hearing Outcome Hearing loss N (%) | Complete Recovery | Partial Recovery | Slight Improvement | No Improvement | Non-Serviceable Ear | Total Number of Cases/Hearing Loss Grade |
Grade 1 | 16 (10) | 0 | 0 | 15 (9) | 0 | 31 (18) |
Grade 2 | 11 (6.5) | 6 (3) | 0 | 25 (15) | 0 | 42 (24.5) |
Grade 3 | 11 (6.5) | 8 (5) | 1 (0.5) | 33 (19.5) | 0 | 53 (31) |
Grade 4 | 1 (0.5) | 4 (2) | 3 (1.5) | 14 (8) | 0 | 22 (13) |
Grade 5 | 0 | 2 (1) | 4 (2) | 0 | 17 (10) | 23 (13.5) |
Total number of cases/outcome | 39 (23) | 20 (12) | 8 (4) | 87 (51) | 17 (10) |
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Thai-Van, H.; Bagheri, H.; Valnet-Rabier, M.-B. Sudden Sensorineural Hearing Loss after COVID-19 Vaccination: A Review of the Available Evidence through the Prism of Causality Assessment. Vaccines 2024, 12, 181. https://doi.org/10.3390/vaccines12020181
Thai-Van H, Bagheri H, Valnet-Rabier M-B. Sudden Sensorineural Hearing Loss after COVID-19 Vaccination: A Review of the Available Evidence through the Prism of Causality Assessment. Vaccines. 2024; 12(2):181. https://doi.org/10.3390/vaccines12020181
Chicago/Turabian StyleThai-Van, Hung, Haleh Bagheri, and Marie-Blanche Valnet-Rabier. 2024. "Sudden Sensorineural Hearing Loss after COVID-19 Vaccination: A Review of the Available Evidence through the Prism of Causality Assessment" Vaccines 12, no. 2: 181. https://doi.org/10.3390/vaccines12020181
APA StyleThai-Van, H., Bagheri, H., & Valnet-Rabier, M.-B. (2024). Sudden Sensorineural Hearing Loss after COVID-19 Vaccination: A Review of the Available Evidence through the Prism of Causality Assessment. Vaccines, 12(2), 181. https://doi.org/10.3390/vaccines12020181