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Localization of Free and Bound Metal Species through X-Ray Synchrotron Fluorescence Microscopy in the Rodent Brain and Their Relation to Behavior

1
Department of Psychology, George Mason University, 4400 University Drive, Fairfax, VA 22030, USA
2
Department of Psychology & Sociology, Angelo State University, 2601 W. Avenue N, ASU Station #10907, San Angelo, TX 76909, USA
3
Center for Advanced Radiation Sources, University of Chicago, 9700 South Cass Avenue, Argonne, IL 60439, USA
*
Author to whom correspondence should be addressed.
Brain Sci. 2019, 9(4), 74; https://doi.org/10.3390/brainsci9040074
Received: 4 March 2019 / Revised: 23 March 2019 / Accepted: 26 March 2019 / Published: 28 March 2019
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Abstract

Biometals in the brain, such as zinc, copper, and iron, are often discussed in cases of neurological disorders; however, these metals also have important regulatory functions and mediate cell signaling and plasticity. With the use of synchrotron X-ray fluorescence, our lab localized total, both bound and free, levels of zinc, copper, and iron in a cross section of one hemisphere of a rat brain, which also showed differing metal distributions in different regions within the hippocampus, the site in the brain known to be crucial for certain types of memory. This review discusses the several roles of these metals in brain regions with an emphasis on hippocampal cell signaling, based on spatial mapping obtained from X-ray fluorescence microscopy. We also discuss the localization of these metals and emphasize different cell types and receptors in regions with metal accumulation, as well as the potential relationship between this physiology and behavior. View Full-Text
Keywords: zinc; copper; iron; long-term potentiation; X-ray fluorescence zinc; copper; iron; long-term potentiation; X-ray fluorescence
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Neely, C.L.C.; Lippi, S.L.P.; Lanzirotti, A.; Flinn, J.M. Localization of Free and Bound Metal Species through X-Ray Synchrotron Fluorescence Microscopy in the Rodent Brain and Their Relation to Behavior. Brain Sci. 2019, 9, 74.

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