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Volume 9
Issue 14
10.3390/app9142849
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Article

Multi Simulation Platform for Time Domain Diffuse Optical Tomography: An Application to a Compact Hand-Held Reflectance Probe

by
Edoardo Ferocino
1,*,
Antonio Pifferi
1,2,
Simon Arridge
3,
Fabrizio Martelli
4,
Paola Taroni
1,2 and
Andrea Farina
2
1
Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci, 32, 20133 Milan, Italy
2
Consiglio Nazionale delle Ricerche, Istituto di Fotonica e Nanotecnologie, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133 Milan, Italy
3
Department of Computer Science, University College London, Gower Street, London WC1E 6BT, UK
4
Dipartimento di Fisica e Astronomia, Università degli Studi di Firenze, Via G. Sansone 1, 50019 Sesto Fiorentino, Firenze, Italy
*
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(14), 2849; https://doi.org/10.3390/app9142849
Submission received: 24 May 2019 / Revised: 3 July 2019 / Accepted: 15 July 2019 / Published: 17 July 2019
(This article belongs to the Special Issue Diffuse Optical Spectroscopy: Advances Towards Widespread Applications)
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Abstract

Time Domain Diffuse Optical Tomography (TD-DOT) enables a full 3D reconstruction of the optical properties of tissue, and could be used for non-invasive and cost-effective in-depth body exploration (e.g., thyroid and breast imaging). Performance quantification is crucial for comparing results coming from different implementations of this technique. A general-purpose simulation platform for TD-DOT clinical systems was developed with a focus on performance assessment through meaningful figures of merit. The platform was employed for assessing the feasibility and characterizing a compact hand-held probe for breast imaging and characterization in reflectance geometry. Important parameters such as hardware gating of the detector, photon count rate and inclusion position were investigated. Results indicate a reduced error (<10%) on the absorption coefficient quantification of a simulated inclusion up to 2-cm depth if a photon count rate ≥ 106 counts per second is used along with a good localization (error < 1 mm down to 25 mm-depth).
Keywords: diffuse optics; optical mammography; diffuse optical tomography; time domain diffuse optics; optical mammography; diffuse optical tomography; time domain

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MDPI and ACS Style

Ferocino, E.; Pifferi, A.; Arridge, S.; Martelli, F.; Taroni, P.; Farina, A. Multi Simulation Platform for Time Domain Diffuse Optical Tomography: An Application to a Compact Hand-Held Reflectance Probe. Appl. Sci. 2019, 9, 2849. https://doi.org/10.3390/app9142849

AMA Style

Ferocino E, Pifferi A, Arridge S, Martelli F, Taroni P, Farina A. Multi Simulation Platform for Time Domain Diffuse Optical Tomography: An Application to a Compact Hand-Held Reflectance Probe. Applied Sciences. 2019; 9(14):2849. https://doi.org/10.3390/app9142849

Chicago/Turabian Style

Ferocino, Edoardo, Antonio Pifferi, Simon Arridge, Fabrizio Martelli, Paola Taroni, and Andrea Farina. 2019. "Multi Simulation Platform for Time Domain Diffuse Optical Tomography: An Application to a Compact Hand-Held Reflectance Probe" Applied Sciences 9, no. 14: 2849. https://doi.org/10.3390/app9142849

APA Style

Ferocino, E., Pifferi, A., Arridge, S., Martelli, F., Taroni, P., & Farina, A. (2019). Multi Simulation Platform for Time Domain Diffuse Optical Tomography: An Application to a Compact Hand-Held Reflectance Probe. Applied Sciences, 9(14), 2849. https://doi.org/10.3390/app9142849

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