Phase Angle and Bioelectrical Impedance Vector Analysis (BIVA) in Amyotrophic Lateral Sclerosis (ALS) Patients
Abstract
:Featured Application
Abstract
1. Introduction
2. Materials and Methods
2.1. Ethical Aspects and Sample Characterization
2.2. Functional Status and Anthropometry
2.3. Bioelectrical Impedance Analysis
2.4. Phase Angle and Bioelectrical Impedance Vector Analysis
2.5. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Tandan, R.; Levy, E.A.; Howard, D.B.; Hiser, J.; Kokinda, N.; Dey, S.; Kasarskis, E.J. Body Composition in Amyotrophic Lateral Sclerosis Subjects and Its Effect on Disease Progression and Survival. Am. J. Clin. Nutr. 2022, 115, 1378–1392. [Google Scholar] [CrossRef]
- D’Amico, E.; Grosso, G.; Nieves, J.W.; Zanghì, A.; Factor-Litvak, P.; Mitsumoto, H. Metabolic Abnormalities, Dietary Risk Factors and Nutritional Management in Amyotrophic Lateral Sclerosis. Nutrients 2021, 13, 2273. [Google Scholar] [CrossRef]
- De Marchi, F.; Carrarini, C.; De Martino, A.; Diamanti, L.; Fasano, A.; Lupica, A.; Russo, M.; Salemme, S.; Spinelli, E.G.; Bombaci, A. Cognitive Dysfunction in Amyotrophic Lateral Sclerosis: Can We Predict It? Neurol. Sci. 2021, 42, 2211–2222. [Google Scholar] [CrossRef]
- Masrori, P.; Van Damme, P. Amyotrophic Lateral Sclerosis: A Clinical Review. Eur. J. Neurol. 2020, 27, 1918–1929. [Google Scholar] [CrossRef]
- Burgos, R.; Bretón, I.; Cereda, E.; Desport, J.C.; Dziewas, R.; Genton, L.; Gomes, F.; Jésus, P.; Leischker, A.; Muscaritoli, M.; et al. ESPEN Guideline Clinical Nutrition in Neurology. Clin. Nutr. 2018, 37, 354–396. [Google Scholar] [CrossRef]
- Lyon, M.S.; Wosiski-Kuhn, M.; Gillespie, R.; Caress, J.; Milligan, C. Inflammation, Immunity, and Amyotrophic Lateral Sclerosis: I. Etiology and Pathology. Muscle Nerve 2019, 59, 10–22. [Google Scholar] [CrossRef]
- Longinetti, E.; Fang, F. Epidemiology of Amyotrophic Lateral Sclerosis: An Update of Recent Literature. Curr. Opin. Neurol. 2019, 32, 771–776. [Google Scholar] [CrossRef]
- Ajroud-Driss, S.; Siddique, T. Sporadic and Hereditary Amyotrophic Lateral Sclerosis (ALS). Biochim. Biophys. Acta Mol. Basis Dis. 2015, 1852, 679–684. [Google Scholar] [CrossRef]
- Brooks, B.R.; Miller, R.G.; Swash, M.; Munsat, T.L. El Escorial Revisited: Revised Criteria for the Diagnosis of Amyotrophic Lateral Sclerosis. Amyotroph. Lateral Scler. Mot. Neuron Disord. 2000, 1, 293–299. [Google Scholar] [CrossRef]
- Del Olmo García, M.D.; Virgili Casas, N.; Cantón Blanco, A.; Lozano Fuster, F.M.; Wanden-Berghe, C.; Avilés, V.; Ashbaugh Enguídanos, R.; Ferrero López, I.; Molina Soria, J.B.; Montejo González, J.C.; et al. Manejo Nutricional de La Esclerosis Lateral Amiotrófica: Resumen de Recomendaciones. Nutr. Hosp. 2018, 35, 1243. [Google Scholar] [CrossRef]
- Shoesmith, C.; Abrahao, A.; Benstead, T.; Chum, M.; Dupre, N.; Izenberg, A.; Johnston, W.; Kalra, S.; Leddin, D.; O’Connell, C.; et al. Canadian Best Practice Recommendations for the Management of Amyotrophic Lateral Sclerosis. Can. Med. Assoc. J. 2020, 192, E1453–E1468. [Google Scholar] [CrossRef]
- Miller, R.G.; Mitchell, J.D.; Moore, D.H. Riluzole for Amyotrophic Lateral Sclerosis (ALS)/Motor Neuron Disease (MND). Cochrane Database Syst. Rev. 2012, 3, CD001447. [Google Scholar] [CrossRef]
- Okada, M.; Yamashita, S.; Ueyama, H.; Ishizaki, M.; Maeda, Y.; Ando, Y. Long-Term Effects of Edaravone on Survival of Patients with Amyotrophic Lateral Sclerosis. eNeurologicalSci 2018, 11, 11–14. [Google Scholar] [CrossRef]
- Paipa, A.J.; Povedano, M.; Barcelo, M.A.; Domínguez, R.; Saez, M.; Turon-Sans, J.; Prats, E.; Farrero, E.; Virgili, M.; Martínez Matos, J.; et al. Survival Benefit of Multidisciplinary Care in Amyotrophic Lateral Sclerosis in Spain: Association with Noninvasive Mechanical Ventilation. J. Multidiscip. Healthc. 2019, 12, 465–470. [Google Scholar] [CrossRef]
- Li, J.-Y.; Sun, X.-H.; Cai, Z.-Y.; Shen, D.; Yang, X.-Z.; Liu, M.-S.; Cui, L.-Y. Correlation of Weight and Body Composition with Disease Progression Rate in Patients with Amyotrophic Lateral Sclerosis. Sci. Rep. 2022, 12, 13292. [Google Scholar] [CrossRef]
- Xia, K.; Wang, Y.; Zhang, L.; Tang, L.; Zhang, G.; Huang, T.; Huang, N.; Fan, D. Dietary-Derived Essential Nutrients and Amyotrophic Lateral Sclerosis: A Two-Sample Mendelian Randomization Study. Nutrients 2022, 14, 920. [Google Scholar] [CrossRef]
- Schimmel, M.; Leuchter, I.; Héritier Barras, A.-C.; Leles, C.R.; Abou-Ayash, S.; Viatte, V.; Esteve, F.; Janssens, J.-P.; Mueller, F.; Genton, L. Oral Function in Amyotrophic Lateral Sclerosis Patients: A Matched Case–Control Study. Clin. Nutr. 2021, 40, 4904–4911. [Google Scholar] [CrossRef]
- Roubeau, V.; Blasco, H.; Maillot, F.; Corcia, P.; Praline, J. Nutritional Assessment of Amyotrophic Lateral Sclerosis in Routine Practice: Value of Weighing and Bioelectrical Impedance Analysis. Muscle Nerve 2015, 51, 479–484. [Google Scholar] [CrossRef]
- Desport, J.C.; Preux, P.M.; Bouteloup-Demange, C.; Clavelou, P.; Beaufrère, B.; Bonnet, C.; Couratier, P.P. Validation of Bioelectrical Impedance Analysis in Patients with Amyotrophic Lateral Sclerosis. Am. J. Clin. Nutr. 2003, 77, 1179–1185. [Google Scholar] [CrossRef]
- Silleras, B.D.M.; Ares, G.C.; Marcos, S.D.L.C.; Enciso, L.C.; Fernández, E.Q.; Río, P.R.D. Bioelectrical Impedance Vector Analysis (BIVA) and Somatotype in Female Rugby Players. Appl. Sci. 2023, 13, 5242. [Google Scholar] [CrossRef]
- Caparello, G.; Galluccio, A.; Ceraudo, F.; Pecorella, C.; Buzzanca, F.; Cuccomarino, F.; Bonofiglio, D.; Avolio, E. Evaluation of Body Composition Changes by Bioelectrical Impedance Vector Analysis in Volleyball Athletes Following Mediterranean Diet Recommendations during Italian Championship: A Pilot Study. Appl. Sci. 2023, 13, 2794. [Google Scholar] [CrossRef]
- Kyle, U.G.; Bosaeus, I.; De Lorenzo, A.D.; Deurenberg, P.; Elia, M.; Gómez, J.M.; Heitmann, B.L.; Kent-Smith, L.; Melchior, J.-C.; Pirlich, M.; et al. Bioelectrical Impedance Analysis? Part I: Review of Principles and Methods. Clin. Nutr. 2004, 23, 1226–1243. [Google Scholar] [CrossRef]
- Piccoli, A. Bioelectric Impedance Measurement for Fluid Status Assessment. In Contributions to Nephrology: Fluid Overload: Diagnosis and Management; Karger: Basel, Switzerland, 2010; Volume 164, pp. 143–152. [Google Scholar]
- Lukaski, H.C.; Vega Diaz, N.; Talluri, A.; Nescolarde, L. Classification of Hydration in Clinical Conditions: Indirect and Direct Approaches Using Bioimpedance. Nutrients 2019, 11, 809. [Google Scholar] [CrossRef]
- Bauermann, A.; Costa e Silva, A.D.A.; Figueiredo, F.; Koury, J.C. Bioelectrical Impedance Vector Analysis and Body Composition in Cervical Spinal Cord Injury: A Pilot Study. Front. Nutr. 2022, 9, 935128. [Google Scholar] [CrossRef]
- Vermeulen, K.M.; Lopes, M.M.G.D.; Grilo, E.C.; Alves, C.X.; Machado, R.J.A.; Lais, L.L.; Brandão-neto, J.; Vale, S.H.L. Bioelectrical Impedance Vector Analysis and Phase Angle in Boys with Duchenne Muscular Dystrophy. Food Nutr. Res. 2019, 1, 1–9. [Google Scholar] [CrossRef]
- Cova, I.; Pomati, S.; Maggiore, L.; Forcella, M.; Cucumo, V.; Ghiretti, R.; Grande, G.; Muzio, F.; Mariani, C. Nutritional Status and Body Composition by Bioelectrical Impedance Vector Analysis: A Cross Sectional Study in Mild Cognitive Impairment and Alzheimer’s Disease. PLoS ONE 2017, 12, e0171331. [Google Scholar] [CrossRef]
- Do Nascimento, T.G.; Paes-Silva, R.P.; da Luz, M.C.L.; Cabral, P.C.; de Araújo Bezerra, G.K.; Gomes, A.C.B. Phase Angle, Muscle Mass, and Functionality in Patients with Parkinson’s Disease. Neurol. Sci. 2022, 43, 4203–4209. [Google Scholar] [CrossRef]
- Di Battista, M.; Barsotti, S.; Monaco, A.; Rossi, A.; Della Rossa, A.; Mosca, M. Bioelectrical Impedance Vector Analysis for Nutritional Status Assessment in Systemic Sclerosis and Association with Disease Characteristics. J. Rheumatol. 2021, 48, 728–734. [Google Scholar] [CrossRef]
- Jager, J.; Putnick, D.L.; Bornstein, M.H., II. More Than Just Convenient: The Scientific Merits of Homogeneous Convenience Samples. Monogr. Soc. Res. Child. Dev. 2017, 82, 13–30. [Google Scholar] [CrossRef]
- De Marchi, F.; Sarnelli, M.F.; Serioli, M.; De Marchi, I.; Zani, E.; Bottone, N.; Ambrosini, S.; Garone, R.; Cantello, R.; Mazzini, L.; et al. Telehealth Approach for Amyotrophic Lateral Sclerosis Patients: The Experience during COVID-19 Pandemic. Acta Neurol. Scand. 2021, 143, 489–496. [Google Scholar] [CrossRef]
- Tarlarini, C.; Greco, L.C.; Lizio, A.; Gerardi, F.; Sansone, V.A.; Lunetta, C. Taste Changes in Amyotrophic Lateral Sclerosis and Effects on Quality of Life. Neurol. Sci. 2019, 40, 399–404. [Google Scholar] [CrossRef] [PubMed]
- Lee, I.; Kazamel, M.; McPherson, T.; McAdam, J.; Bamman, M.; Amara, A.; Smith, D.L.; King, P.H. Fat Mass Loss Correlates with Faster Disease Progression in Amyotrophic Lateral Sclerosis Patients: Exploring the Utility of Dual-Energy X-Ray Absorptiometry in a Prospective Study. PLoS ONE 2021, 16, e0251087. [Google Scholar] [CrossRef] [PubMed]
- Kyle, U.G.; Bosaeus, I.; De Lorenzo, A.D.; Deurenberg, P.; Elia, M.; Manuel Gómez, J.; Lilienthal Heitmann, B.; Kent-Smith, L.; Melchior, J.-C.; Pirlich, M.; et al. Bioelectrical Impedance Analysis—Part II: Utilization in Clinical Practice. Clin. Nutr. 2004, 23, 1430–1453. [Google Scholar] [CrossRef]
- Cedarbaum, J.M.; Stambler, N.; Malta, E.; Fuller, C.; Hilt, D.; Thurmond, B.; Nakanishi, A. The ALSFRS-R: A Revised ALS Functional Rating Scale That Incorporates Assessments of Respiratory Function. J. Neurol. Sci. 1999, 169, 13–21. [Google Scholar] [CrossRef] [PubMed]
- Lukaski, H.C.; Bolonchuk, W.W.; Hall, C.B.; Siders, W.A. Validation of Tetrapolar Bioelectrical Impedance Method to Assess Human Body Composition. J. Appl. Physiol. 1986, 60, 1327–1332. [Google Scholar] [CrossRef]
- Baumgartner, R.; Chumlea, W.; Roche, A. Bioelectric Impedance Phase Angle and Body Composition. Am. J. Clin. Nutr. 1988, 48, 16–23. [Google Scholar] [CrossRef]
- Piccoli, A.; Nigrelli, S.; Caberlotto, A.; Bottazzo, S.; Rossi, B.; Pillon, L.; Maggiore, Q. Bivariate Normal Values of the Bioelectrical Impedance Vector in Adult and Elderly Populations. Am. J. Clin. Nutr. 1995, 61, 269–270. [Google Scholar] [CrossRef]
- Piccoli, A.; Pastori, G. BIVA Software 2002; Department of Medical and Surgical Sciences, University of Padova: Padova, Italy, 2002. [Google Scholar]
- Redondo-del-Río, M.P.; Camina-Martín, M.A.; Marugán-de-Miguelsanz, J.; de-Mateo-Silleras, B. Bioelectrical Impedance Vector Reference Values for Assessing Body Composition in a Spanish Child and Adolescent Population. Am. J. Hum. Biol. 2017, 29, e22978. [Google Scholar] [CrossRef]
- Fayemendy, P.; Marin, B.; Labrunie, A.; Boirie, Y.; Walrand, S.; Achamrah, N.; Coëffier, M.; Preux, P.-M.; Lautrette, G.; Desport, J.-C.; et al. Hypermetabolism Is a Reality in Amyotrophic Lateral Sclerosis Compared to Healthy Subjects. J. Neurol. Sci. 2021, 420, 117257. [Google Scholar] [CrossRef]
- Marin, B.; Desport, J.C.; Kajeu, P.; Jesus, P.; Nicolaud, B.; Nicol, M.; Preux, P.M.; Couratier, P. Alteration of Nutritional Status at Diagnosis Is a Prognostic Factor for Survival of Amyotrophic Lateral Sclerosis Patients. J. Neurol. Neurosurg. Psychiatry 2011, 82, 628–634. [Google Scholar] [CrossRef]
- Kellogg, J.; Bottman, L.; Arra, E.J.; Selkirk, S.M.; Kozlowski, F. Nutrition Management Methods Effective in Increasing Weight, Survival Time and Functional Status in ALS Patients: A Systematic Review. Amyotroph. Lateral Scler. Front. Degener. 2018, 19, 7–11. [Google Scholar] [CrossRef] [PubMed]
- Park, J.-W.; Kim, M.; Baek, S.-H.; Sung, J.H.; Yu, J.-G.; Kim, B.-J. Body Fat Percentage and Availability of Oral Food Intake: Prognostic Factors and Implications for Nutrition in Amyotrophic Lateral Sclerosis. Nutrients 2021, 13, 3704. [Google Scholar] [CrossRef] [PubMed]
- Kasarskis, E.J.; Mendiondo, M.S.; Matthews, D.E.; Mitsumoto, H.; Tandan, R.; Simmons, Z.; Bromberg, M.B.; Kryscio, R.J. Estimating Daily Energy Expenditure in Individuals with Amyotrophic Lateral Sclerosis. Am. J. Clin. Nutr. 2014, 99, 792–803. [Google Scholar] [CrossRef] [PubMed]
- D’Antona, S.; Caramenti, M.; Porro, D.; Castiglioni, I.; Cava, C. Amyotrophic Lateral Sclerosis: A Diet Review. Foods 2021, 10, 3128. [Google Scholar] [CrossRef] [PubMed]
- Bouteloup, C.; Desport, J.-C.; Clavelou, P.; Guy, N.; Derumeaux-Burel, H.; Ferrier, A.; Couratier, P. Hypermetabolism in ALS Patients: An Early and Persistent Phenomenon. J. Neurol. 2009, 256, 1236–1242. [Google Scholar] [CrossRef]
- Steyn, F.J.; Ioannides, Z.A.; van Eijk, R.P.A.; Heggie, S.; Thorpe, K.A.; Ceslis, A.; Heshmat, S.; Henders, A.K.; Wray, N.R.; van den Berg, L.H.; et al. Hypermetabolism in ALS Is Associated with Greater Functional Decline and Shorter Survival. J. Neurol. Neurosurg. Psychiatry 2018, 89, 1016–1023. [Google Scholar] [CrossRef]
- Vercruysse, P.; Vieau, D.; Blum, D.; Petersén, Å.; Dupuis, L. Hypothalamic Alterations in Neurodegenerative Diseases and Their Relation to Abnormal Energy Metabolism. Front. Mol. Neurosci. 2018, 11, 2. [Google Scholar] [CrossRef]
- Kurihara, M.; Bamba, S.; Yasuhara, S.; Itoh, A.; Nagao, T.; Nakanishi, N.; Nakamura, R.; Ogawa, N.; Kitamura, A.; Yamakawa, I.; et al. Factors Affecting Energy Metabolism and Prognosis in Patients with Amyotrophic Lateral Sclerosis. Ann. Nutr. Metab. 2021, 77, 236–243. [Google Scholar] [CrossRef]
- Barone, M.; Viggiani, M.T.; Introna, A.; D’errico, E.; Scarafino, A.; Iannone, A.; Di Leo, A.; Simone, I.L. Nutritional Prognostic Factors for Survival in Amyotrophic Lateral Sclerosis Patients Undergone Percutaneous Endoscopic Gastrostomy Placement. Amyotroph. Lateral Scler. Front. Degener. 2019, 20, 490–496. [Google Scholar] [CrossRef]
- Ngo, S.T.; Steyn, F.J.; McCombe, P.A. Body Mass Index and Dietary Intervention: Implications for Prognosis of Amyotrophic Lateral Sclerosis. J. Neurol. Sci. 2014, 340, 5–12. [Google Scholar] [CrossRef]
- Vandoorne, T.; De Bock, K.; Van Den Bosch, L. Energy Metabolism in ALS: An Underappreciated Opportunity? Acta Neuropathol. 2018, 135, 489–509. [Google Scholar] [CrossRef] [PubMed]
- Dupuis, L.; Pradat, P.-F.; Ludolph, A.C.; Loeffler, J.-P. Energy Metabolism in Amyotrophic Lateral Sclerosis. Lancet Neurol. 2011, 10, 75–82. [Google Scholar] [CrossRef] [PubMed]
- He, J.; Fu, J.; Zhao, W.; Ren, C.; Liu, P.; Chen, L.; Li, D.; Tang, L.; Zhou, L.; Zhang, Y.; et al. Hypermetabolism Associated with Worse Prognosis of Amyotrophic Lateral Sclerosis. J. Neurol. 2022, 269, 1447–1455. [Google Scholar] [CrossRef] [PubMed]
- Nakamura, R.; Kurihara, M.; Ogawa, N.; Kitamura, A.; Yamakawa, I.; Bamba, S.; Sanada, M.; Sasaki, M.; Urushitani, M. Prognostic Prediction by Hypermetabolism Varies Depending on the Nutritional Status in Early Amyotrophic Lateral Sclerosis. Sci. Rep. 2021, 11, 17943. [Google Scholar] [CrossRef] [PubMed]
- Holdom, C.J.; Janse van Mantgem, M.R.; Eijk, R.P.A.; Howe, S.L.; Berg, L.H.; McCombe, P.A.; Henderson, R.D.; Ngo, S.T.; Steyn, F.J. Venous Creatinine as a Biomarker for Loss of Fat-free Mass and Disease Progression in Patients with Amyotrophic Lateral Sclerosis. Eur. J. Neurol. 2021, 28, 3615–3625. [Google Scholar] [CrossRef] [PubMed]
- Calcaterra, V.; Cena, H.; Manuelli, M.; Sacchi, L.; Girgenti, V.; Larizza, C.; Pelizzo, G. Body Hydration Assessment Using Bioelectrical Impedance Vector Analysis in Neurologically Impaired Children. Eur. J. Clin. Nutr. 2019, 73, 1649–1652. [Google Scholar] [CrossRef] [PubMed]
- Scagnelli, C.N.; Howard, D.B.; Bromberg, M.B.; Kasarskis, E.J.; Matthews, D.E.; Mitsumoto, H.M.; Simmons, Z.; Tandan, R. Hydration Measured by Doubly Labeled Water in ALS and Its Effects on Survival. Amyotroph. Lateral Scler. Front. Degener. 2018, 19, 220–231. [Google Scholar] [CrossRef]
- Desport, J.-C.; Marin, B.; Funalot, B.; Preux, P.-M.; Couratier, P. Phase Angle Is a Prognostic Factor for Survival in Amyotrophic Lateral Sclerosis. Amyotroph. Lateral Scler. 2008, 9, 273–278. [Google Scholar] [CrossRef]
- Tanaka, S.; Ando, K.; Kobayashi, K.; Hida, T.; Seki, T.; Hamada, T.; Ito, K.; Tsushima, M.; Morozumi, M.; Machino, M.; et al. The Decrease in Phase Angle Measured by Bioelectrical Impedance Analysis Reflects the Increased Locomotive Syndrome Risk in Community-Dwelling People: The Yakumo Study. Mod. Rheumatol. 2019, 29, 496–502. [Google Scholar] [CrossRef]
- Ellegård, L.; Aldenbratt, A.; Svensson, M.K.; Lindberg, C. Body Composition in Patients with Primary Neuromuscular Disease Assessed by Dual Energy X-Ray Absorptiometry (DXA) and Three Different Bioimpedance Devices. Clin. Nutr. ESPEN 2019, 29, 142–148. [Google Scholar] [CrossRef]
- Santos, M.A.; Goes, A.C.; de Siqueira Oliveira, R.; de Souza Oliveira, J.; Ferreira, A.J.F.; da Silva Santiago, E.C.; Roriz, A.K.C.; de Oliveira, C.C. Association between Phase Angle of Bioelectrical Impedance Analysis and Nutritional Parameters in Older Adults. ABCS Health Sci. 2023, 48, e023210. [Google Scholar] [CrossRef]
- Jiang, F.L.; Tang, S.; Eom, S.H.; Lee, J.Y.; Chae, J.H.; Kim, C.H. Distribution of Bioelectrical Impedance Vector Analysis and Phase Angle in Korean Elderly and Sarcopenia. Sensors 2023, 23, 7090. [Google Scholar] [CrossRef] [PubMed]
- Fukuoka, A.H.; de Oliveira, N.M.; Matias, C.N.; Teixeira, F.J.; Monteiro, C.P.; Valamatos, M.J.; Reis, J.F.; Gonçalves, E.M. Association between Phase Angle from Bioelectric Impedance and Muscular Strength and Power in Physically Active Adults. Biology 2022, 11, 1255. [Google Scholar] [CrossRef] [PubMed]
- Da Silva, B.R.; Orsso, C.E.; Gonzalez, M.C.; Sicchieri, J.M.F.; Mialich, M.S.; Jordao, A.A.; Prado, C.M. Phase Angle and Cellular Health: Inflammation and Oxidative Damage. Rev. Endocr. Metab. Disord. 2023, 24, 543–562. [Google Scholar] [CrossRef] [PubMed]
- Martins, A.D.; Oliveira, R.; Brito, J.P.; Costa, T.; Ramalho, F.; Pimenta, N.; Santos-Rocha, R. Phase Angle Cutoff Value as a Marker of the Health Status and Functional Capacity in Breast Cancer Survivors. Physiol. Behav. 2021, 235, 113400. [Google Scholar] [CrossRef] [PubMed]
- Dorst, J.; Weydt, P.; Brenner, D.; Witzel, S.; Kandler, K.; Huss, A.; Herrmann, C.; Wiesenfarth, M.; Knehr, A.; Günther, K.; et al. Metabolic Alterations Precede Neurofilament Changes in Presymptomatic ALS Gene Carriers. eBioMedicine 2023, 90, 104521. [Google Scholar] [CrossRef]
- Mereu, E.; Succa, V.; Buffa, R.; Sanna, C.; Mereu, R.M.; Catte, O.; Marini, E. Total Body and Arm Bioimpedance in Patients with Alzheimer’s Disease. Exp. Gerontol. 2018, 102, 145–148. [Google Scholar] [CrossRef]
- Barrera Ortega, S.; Redondo del Río, P.; Carreño Enciso, L.; de la Cruz Marcos, S.; Massia, M.N.; de Mateo Silleras, B. Phase Angle as a Prognostic Indicator of Survival in Institutionalized Psychogeriatric Patients. Nutrients 2023, 15, 2139. [Google Scholar] [CrossRef]
- Siváková, D.; Vondrová, D.; Valkovič, P.; Cvíčelová, M.; Danková, Z.; Luptáková, L. Bioelectrical Impedance Vector Analysis (BIVA) in Slovak Population: Application in a Clinical Sample. Open Life Sci. 2013, 8, 1094–1101. [Google Scholar] [CrossRef]
Variable | Cases (n = 20) | Controls (n = 20) | p |
---|---|---|---|
Sex, Male/Female | 11/9 | 11/9 | - |
Age, years | 52.7 (11.6) | 50.3 (10.0) | - |
Body Mass Index, kg/m2 | 21.9 (2.9) | 27.2 (5.1) | 0.0002 |
Fat Mass, Kg | 19.2 (5.8) | 22.1 (9.6) | 0.2616 |
Fat Free Mass, Kg | 37.9 (6.0) | 51.7 (11.0) | <0.0001 |
Total Body Water, Kg | 27.1 (4.3) | 37.4 (8.3) | <0.0001 |
Phase Angle, ° | 3.4 (0.9) | 6.2 (1.0) | <0.0001 |
R/H, Ohm/m | 455.2 (76.4) | 322.4 (73.6) | <0.0001 |
Xc/H, Ohm/m | 26.7 (6.6) | 34.2 (7.3) | 0.0017 |
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Cunha, T.A.; Lopes, M.M.G.D.; de Araújo Brito, A.N.; Vermeulen-Serpa, K.M.; de Lima Vale, S.H.; Brandão-Neto, J.; Leite-Lais, L. Phase Angle and Bioelectrical Impedance Vector Analysis (BIVA) in Amyotrophic Lateral Sclerosis (ALS) Patients. Appl. Sci. 2024, 14, 1545. https://doi.org/10.3390/app14041545
Cunha TA, Lopes MMGD, de Araújo Brito AN, Vermeulen-Serpa KM, de Lima Vale SH, Brandão-Neto J, Leite-Lais L. Phase Angle and Bioelectrical Impedance Vector Analysis (BIVA) in Amyotrophic Lateral Sclerosis (ALS) Patients. Applied Sciences. 2024; 14(4):1545. https://doi.org/10.3390/app14041545
Chicago/Turabian StyleCunha, Thais Alves, Márcia Marília Gomes Dantas Lopes, Acsa Nara de Araújo Brito, Karina Marques Vermeulen-Serpa, Sancha Helena de Lima Vale, José Brandão-Neto, and Lucia Leite-Lais. 2024. "Phase Angle and Bioelectrical Impedance Vector Analysis (BIVA) in Amyotrophic Lateral Sclerosis (ALS) Patients" Applied Sciences 14, no. 4: 1545. https://doi.org/10.3390/app14041545
APA StyleCunha, T. A., Lopes, M. M. G. D., de Araújo Brito, A. N., Vermeulen-Serpa, K. M., de Lima Vale, S. H., Brandão-Neto, J., & Leite-Lais, L. (2024). Phase Angle and Bioelectrical Impedance Vector Analysis (BIVA) in Amyotrophic Lateral Sclerosis (ALS) Patients. Applied Sciences, 14(4), 1545. https://doi.org/10.3390/app14041545