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Applied Sciences
Volume 11
Issue 21
10.3390/app11219991
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Article

Comparison of the Efficacy of Dextrose Prolotherapy and Ozone in Patients with Knee Osteoarthritis: A Randomized Cross-Sectional Study

by
Fatih Baygutalp
1,*,
Mine Çelik
2,
Muhammet Uğur Öztürk
1,
Ahmet Murat Yayık
2 and
Ali Ahıskalıoğlu
2
1
Department of Physical Therapy and Rehabilitation, School of Medicine, Ataturk University, Erzurum 25240, Turkey
2
Department of Anesthesiology and Reanimation, School of Medicine, Ataturk University, Erzurum 25240, Turkey
*
Author to whom correspondence should be addressed.
Appl. Sci. 2021, 11(21), 9991; https://doi.org/10.3390/app11219991
Submission received: 4 October 2021 / Revised: 18 October 2021 / Accepted: 19 October 2021 / Published: 26 October 2021
(This article belongs to the Topic Human Anatomy and Pathophysiology)
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Abstract

This study aimed to compare the effectiveness of dextrose prolotherapy, ozone therapy, and home exercise programs in patients with knee osteoarthritis. Seventy-five patients with knee osteoarthritis were divided into three groups, with 25 in each group. At week 0 (baseline), week 3, and week 6, 12.5% dextrose (intraarticular and periarticular) was administered to the dextrose prolotherapy group. At week 0 (baseline), week 1, and week 2 15 μg/mL ozone (intraarticular and periarticular) was administered to the ozone therapy group. Both groups were also given a home exercise program. The third group was given a home-based exercise therapy program for 12 weeks. All groups were evaluated for VAS, WOMAC, TUG, ROM-active, and ROM-passive values at weeks 0 (baseline), 6, and 12. Ozone therapy more effectively improved VAS scores than dextrose prolotherapy and VAS and WOMAC scores than home-based exercise therapy in the 6th week. Ozone therapy also more effectively improved VAS and WOMAC-stiffness scores than dextrose prolotherapy and VAS, WOMAC, and ROM-active scores than home-based exercise therapy in the 12th week. Both dextrose prolotherapy and ozone therapy are effective in knee osteoarthritis treatment. Ozone therapy should be used in suitable cases rather than dextrose prolotherapy.
Keywords: dextrose prolotherapy; exercise; knee; osteoarthritis; ozone therapy dextrose prolotherapy; exercise; knee; osteoarthritis; ozone therapy

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MDPI and ACS Style

Baygutalp, F.; Çelik, M.; Öztürk, M.U.; Yayık, A.M.; Ahıskalıoğlu, A. Comparison of the Efficacy of Dextrose Prolotherapy and Ozone in Patients with Knee Osteoarthritis: A Randomized Cross-Sectional Study. Appl. Sci. 2021, 11, 9991. https://doi.org/10.3390/app11219991

AMA Style

Baygutalp F, Çelik M, Öztürk MU, Yayık AM, Ahıskalıoğlu A. Comparison of the Efficacy of Dextrose Prolotherapy and Ozone in Patients with Knee Osteoarthritis: A Randomized Cross-Sectional Study. Applied Sciences. 2021; 11(21):9991. https://doi.org/10.3390/app11219991

Chicago/Turabian Style

Baygutalp, Fatih, Mine Çelik, Muhammet Uğur Öztürk, Ahmet Murat Yayık, and Ali Ahıskalıoğlu. 2021. "Comparison of the Efficacy of Dextrose Prolotherapy and Ozone in Patients with Knee Osteoarthritis: A Randomized Cross-Sectional Study" Applied Sciences 11, no. 21: 9991. https://doi.org/10.3390/app11219991

APA Style

Baygutalp, F., Çelik, M., Öztürk, M. U., Yayık, A. M., & Ahıskalıoğlu, A. (2021). Comparison of the Efficacy of Dextrose Prolotherapy and Ozone in Patients with Knee Osteoarthritis: A Randomized Cross-Sectional Study. Applied Sciences, 11(21), 9991. https://doi.org/10.3390/app11219991

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