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Article

Collagen-Based Bioactive Bromelain Hydrolysate from Salt-Cured Cod Skin

CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Universidade Católica Portuguesa, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal
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Academic Editor: Vincenza Ferraro
Appl. Sci. 2021, 11(18), 8538; https://doi.org/10.3390/app11188538
Received: 5 August 2021 / Revised: 31 August 2021 / Accepted: 10 September 2021 / Published: 14 September 2021
Considerable amounts of fish processing by-products are discarded each year. About 30% of this material may be skin and bone. Fish skin has more than 80% of its total protein content as collagen. Furthermore, in recent years, there has been a growing demand for collagen-based peptides due to their beneficial health effects. So, the objective of the present study was to optimise the obtaining bioactive hydrolysates from salt-cured cod skin using the protease Bromelain at 0.5% (w/w) concentration. This study developed a sustainable process that consumes less time and energy and uses an alternative source as raw material. In addition, bromelain allows hydrolysates with important antioxidant (ORAC, 514 μmol Trolox Equivalent/g protein) and antihypertensive activities (inhibition of ACE, IC50 of 166 μg protein/mL) as well as excellent biocompatibility with dermal and subcutaneous cells. View Full-Text
Keywords: Atlantic cod skin; enzymatic hydrolysis; collagen; fishery by-products; bioactive peptides; bromelain; antioxidant; antihypertensive Atlantic cod skin; enzymatic hydrolysis; collagen; fishery by-products; bioactive peptides; bromelain; antioxidant; antihypertensive
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MDPI and ACS Style

Coscueta, E.R.; Brassesco, M.E.; Pintado, M. Collagen-Based Bioactive Bromelain Hydrolysate from Salt-Cured Cod Skin. Appl. Sci. 2021, 11, 8538. https://doi.org/10.3390/app11188538

AMA Style

Coscueta ER, Brassesco ME, Pintado M. Collagen-Based Bioactive Bromelain Hydrolysate from Salt-Cured Cod Skin. Applied Sciences. 2021; 11(18):8538. https://doi.org/10.3390/app11188538

Chicago/Turabian Style

Coscueta, Ezequiel R., María E. Brassesco, and Manuela Pintado. 2021. "Collagen-Based Bioactive Bromelain Hydrolysate from Salt-Cured Cod Skin" Applied Sciences 11, no. 18: 8538. https://doi.org/10.3390/app11188538

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