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Survey of Biosynthetic Gene Clusters from Sequenced Myxobacteria Reveals Unexplored Biosynthetic Potential

Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
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Microorganisms 2019, 7(6), 181; https://doi.org/10.3390/microorganisms7060181
Received: 24 May 2019 / Revised: 20 June 2019 / Accepted: 21 June 2019 / Published: 24 June 2019
Coinciding with the increase in sequenced bacteria, mining of bacterial genomes for biosynthetic gene clusters (BGCs) has become a critical component of natural product discovery. The order Myxococcales, a reputable source of biologically active secondary metabolites, spans three suborders which all include natural product producing representatives. Utilizing the BiG-SCAPE-CORASON platform to generate a sequence similarity network that contains 994 BGCs from 36 sequenced myxobacteria deposited in the antiSMASH database, a total of 843 BGCs with lower than 75% similarity scores to characterized clusters within the MIBiG database are presented. This survey provides the biosynthetic diversity of these BGCs and an assessment of the predicted chemical space yet to be discovered. Considering the mere snapshot of myxobacteria included in this analysis, these untapped BGCs exemplify the potential for natural product discovery from myxobacteria. View Full-Text
Keywords: myxobacteria; biosynthetic gene clusters; natural product discovery myxobacteria; biosynthetic gene clusters; natural product discovery
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MDPI and ACS Style

Gregory, K.; Salvador, L.A.; Akbar, S.; Adaikpoh, B.I.; Stevens, D.C. Survey of Biosynthetic Gene Clusters from Sequenced Myxobacteria Reveals Unexplored Biosynthetic Potential. Microorganisms 2019, 7, 181.

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