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Biosynthesis of Polyketides in Streptomyces

1
Microbial Strain Collection (MISG), Helmholtz Centre for Infection Research (HZI), 38124 Braunschweig, Germany
2
Research Unit for Clean Technology, Indonesian Institute of Sciences (LIPI), Bandung 40135, Indonesia
3
Research Center for Chemistry, Indonesian Institute of Sciences (LIPI), Serpong 15314, Indonesia
*
Authors to whom correspondence should be addressed.
Microorganisms 2019, 7(5), 124; https://doi.org/10.3390/microorganisms7050124
Received: 18 March 2019 / Revised: 24 April 2019 / Accepted: 27 April 2019 / Published: 6 May 2019
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Abstract

Polyketides are a large group of secondary metabolites that have notable variety in their structure and function. Polyketides exhibit a wide range of bioactivities such as antibacterial, antifungal, anticancer, antiviral, immune-suppressing, anti-cholesterol, and anti-inflammatory activity. Naturally, they are found in bacteria, fungi, plants, protists, insects, mollusks, and sponges. Streptomyces is a genus of Gram-positive bacteria that has a filamentous form like fungi. This genus is best known as one of the polyketides producers. Some examples of polyketides produced by Streptomyces are rapamycin, oleandomycin, actinorhodin, daunorubicin, and caprazamycin. Biosynthesis of polyketides involves a group of enzyme activities called polyketide synthases (PKSs). There are three types of PKSs (type I, type II, and type III) in Streptomyces responsible for producing polyketides. This paper focuses on the biosynthesis of polyketides in Streptomyces with three structurally-different types of PKSs. View Full-Text
Keywords: Streptomyces; polyketides; secondary metabolite; polyketide synthases (PKSs) Streptomyces; polyketides; secondary metabolite; polyketide synthases (PKSs)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Risdian, C.; Mozef, T.; Wink, J. Biosynthesis of Polyketides in Streptomyces. Microorganisms 2019, 7, 124.

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