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Open AccessReview

The Revival of the Battle between David and Goliath in the Enteric Viruses and Microbiota Struggle: Potential Implication for Celiac Disease

AESKU.KIPP Institute, Mikroforum Ring 2, 55234 Wendelsheim, Germany
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Microorganisms 2019, 7(6), 173; https://doi.org/10.3390/microorganisms7060173
Received: 29 April 2019 / Revised: 4 June 2019 / Accepted: 11 June 2019 / Published: 14 June 2019
(This article belongs to the Collection Feature Papers in Gut Microbiota)
The human gut is inhabited by overcrowded prokaryotic communities, a major component of which is the virome, comprised of viruses, bacteriophages, archaea, eukaryotes and bacteria. The virome is required for luminal homeostasis and, by their lytic or synergic capacities, they can regulate the microbial community structure and activity. Dysbiosis is associated with numerous chronic human diseases. Since the virome can impact microbial genetics and behavior, understanding its biology, composition, cellular cycle, regulation, mode of action and potential beneficial or hostile activities can change the present paradigm of the cross-talks in the luminal gut compartment. Celiac disease is a frequent autoimmune disease in which viruses can play a role in disease development. Based on the current knowledge on the enteric virome, in relation to celiac disease pathophysiological evolvement, the current review summarizes the potential interphases between the two. Exploring and understanding the role of the enteric virome in gluten-dependent enteropathy might bring new therapeutic strategies to change the luminal eco-event for the patient’s benefit. View Full-Text
Keywords: virus; bacteria; virome; phageome; microbiome; gut; intestinal lumen; horizontal gene transfer; celiac disease virus; bacteria; virome; phageome; microbiome; gut; intestinal lumen; horizontal gene transfer; celiac disease
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Lerner, A.; Ramesh, A.; Matthias, T. The Revival of the Battle between David and Goliath in the Enteric Viruses and Microbiota Struggle: Potential Implication for Celiac Disease. Microorganisms 2019, 7, 173.

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