Next Article in Journal
Inhibition of Nitric Oxide Production, Oxidative Stress Prevention, and Probiotic Activity of Lactic Acid Bacteria Isolated from the Human Vagina and Fermented Food
Next Article in Special Issue
Members of the Lactobacillus Genus Complex (LGC) as Opportunistic Pathogens: A Review
Previous Article in Journal
Systematic Affiliation and Genome Analysis of Subtercola vilae DB165T with Particular Emphasis on Cold Adaptation of an Isolate from a High-Altitude Cold Volcano Lake
Previous Article in Special Issue
Probiotics: If It Does Not Help It Does Not Do Any Harm. Really?
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle

The Anti-Rotaviral Activity of Low Molecular Weight and Non-Proteinaceous Substance from Bifidobacterium longum BORI Cell Extract

1
Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 08826, Korea
2
Research Center, BIFIDO Co., Ltd., Hongcheon 25117, Korea
3
Institute of Health and Environment, Graduate School of Public Health, Seoul National University, Seoul 08826, Korea
4
Fermentation Science Program, School of Agriculture, College of Basic and Applied Sciences, Middle Tennessee State University, Murfreesboro, TN 37132, USA
*
Author to whom correspondence should be addressed.
Microorganisms 2019, 7(4), 108; https://doi.org/10.3390/microorganisms7040108
Received: 19 March 2019 / Revised: 21 April 2019 / Accepted: 22 April 2019 / Published: 23 April 2019
(This article belongs to the Special Issue Safety Aspects of Lactic Acid Bacteria)
  |  
PDF [1517 KB, uploaded 23 April 2019]
  |     |  

Abstract

Rotavirus infection is the most common diarrheal disease worldwide in children under five years of age, and it often results in death. In recent years, research on the relationship between rotavirus and probiotics has shown that probiotics are effective against diarrhea. A clinical trial has reported that Bifidobacterium longum BORI reduced diarrhea induced by rotavirus. The present work investigated the anti-rotaviral effect of B. longum BORI by cytopathic effect observation and real time cell analyses. Our study found that B. longum BORI showed strong anti-rotaviral effect when incubated with MA104 cells prior to viral infection, suggesting that the probiotic does in fact interfere with the interaction of viruses and host cells. It is believed that the efficacy is due to low-molecular weight and non-protein components derived from B. longum BORI. This discovery can help broaden the industrial application of B. longum BORI, which has been proven to be a safe and effective probiotic. View Full-Text
Keywords: rotavirus infection; Bifidobacterium longum BORI; probiotics; cytopathic effect; real time cell analysis rotavirus infection; Bifidobacterium longum BORI; probiotics; cytopathic effect; real time cell analysis
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Han, Y.O.; Jeong, Y.; You, H.J.; Ku, S.; Ji, G.E.; Park, M.S. The Anti-Rotaviral Activity of Low Molecular Weight and Non-Proteinaceous Substance from Bifidobacterium longum BORI Cell Extract. Microorganisms 2019, 7, 108.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Microorganisms EISSN 2076-2607 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top