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Open AccessReview

Current Status and Potential Applications of Underexplored Prokaryotes

1
Faculty of Science, Universiti Teknologi Malaysia, Skudai 81310, Johor, Malaysia
2
Division of Genetics and Molecular Biology, Institute of Biological Science, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
3
International Genome Centre, Jiangsu University, ZhenJiang 212013, China
4
Malaysia Genome Institute, National Institutes of Biotechnology Malaysia, Jalan Bangi, Kajang 43000, Selangor, Malaysia
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Microorganisms 2019, 7(10), 468; https://doi.org/10.3390/microorganisms7100468
Received: 13 August 2019 / Revised: 5 October 2019 / Accepted: 8 October 2019 / Published: 18 October 2019
(This article belongs to the Special Issue Microbial Diversity in Extreme Environments)
Thousands of prokaryotic genera have been published, but methodological bias in the study of prokaryotes is noted. Prokaryotes that are relatively easy to isolate have been well-studied from multiple aspects. Massive quantities of experimental findings and knowledge generated from the well-known prokaryotic strains are inundating scientific publications. However, researchers may neglect or pay little attention to the uncommon prokaryotes and hard-to-cultivate microorganisms. In this review, we provide a systematic update on the discovery of underexplored culturable and unculturable prokaryotes and discuss the insights accumulated from various research efforts. Examining these neglected prokaryotes may elucidate their novelties and functions and pave the way for their industrial applications. In addition, we hope that this review will prompt the scientific community to reconsider these untapped pragmatic resources. View Full-Text
Keywords: ex situ diffusion bioreactor; ichip; metagenome-assembled genome; rare microorganisms; shotgun metagenome sequencing; unculturable bacteria ex situ diffusion bioreactor; ichip; metagenome-assembled genome; rare microorganisms; shotgun metagenome sequencing; unculturable bacteria
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Goh, K.M.; Shahar, S.; Chan, K.-G.; Chong, C.S.; Amran, S.I.; Sani, M.H.; Zakaria, I.I.; Kahar, U.M. Current Status and Potential Applications of Underexplored Prokaryotes. Microorganisms 2019, 7, 468.

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