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Microorganisms
Volume 7
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10.3390/microorganisms7100429
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Review

Current and Emerging Therapies for Ocular Herpes Simplex Virus Type-1 Infections

by
Raghuram Koganti
1,
Tejabhiram Yadavalli
1 and
Deepak Shukla
1,2,*
1
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1855 W. Taylor St, Chicago, IL 60612, USA
2
Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA
*
Author to whom correspondence should be addressed.
Microorganisms 2019, 7(10), 429; https://doi.org/10.3390/microorganisms7100429
Submission received: 4 September 2019 / Revised: 2 October 2019 / Accepted: 3 October 2019 / Published: 10 October 2019
(This article belongs to the Special Issue Insights Into The Molecular Pathogenesis of Ocular Infections)
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Abstract

Herpes simplex virus type-1 (HSV-1) is a neurotropic, double-stranded DNA virus that can cause a wide variety of diseases, including many ocular pathologies. It is one of the leading causes of infectious blindness in the United States. Because of its ubiquitous nature and its potential to cause serious ocular maladies, there is a significant need for more effective antiviral therapies against ocular HSV-1. In this review, we discuss the lifecycle of HSV-1 as it pertains to corneal infections and the clinically approved as well as emerging treatments to combat HSV-1 infections. We also highlight some newly identified host targets for the antiviral drug development.
Keywords: herpes simplex virus; herpesvirus; keratitis; ocular therapy; antiviral; acyclovir herpes simplex virus; herpesvirus; keratitis; ocular therapy; antiviral; acyclovir

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MDPI and ACS Style

Koganti, R.; Yadavalli, T.; Shukla, D. Current and Emerging Therapies for Ocular Herpes Simplex Virus Type-1 Infections. Microorganisms 2019, 7, 429. https://doi.org/10.3390/microorganisms7100429

AMA Style

Koganti R, Yadavalli T, Shukla D. Current and Emerging Therapies for Ocular Herpes Simplex Virus Type-1 Infections. Microorganisms. 2019; 7(10):429. https://doi.org/10.3390/microorganisms7100429

Chicago/Turabian Style

Koganti, Raghuram, Tejabhiram Yadavalli, and Deepak Shukla. 2019. "Current and Emerging Therapies for Ocular Herpes Simplex Virus Type-1 Infections" Microorganisms 7, no. 10: 429. https://doi.org/10.3390/microorganisms7100429

APA Style

Koganti, R., Yadavalli, T., & Shukla, D. (2019). Current and Emerging Therapies for Ocular Herpes Simplex Virus Type-1 Infections. Microorganisms, 7(10), 429. https://doi.org/10.3390/microorganisms7100429

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