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Open AccessArticle

Synthesis and Evaluation of Novel Ellipticines and Derivatives as Inhibitors of Phytophthora infestans

1
School of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, T12 K8AF Cork, Ireland
2
Department of Physiology, School of Medicine, University College Cork, Western Road, T12 K8AF Cork, Ireland
3
School of Biological, Earth and Environmental Sciences, University College Cork, Western Road, T12 K8AF Cork, Ireland
*
Authors to whom correspondence should be addressed.
Pathogens 2020, 9(7), 558; https://doi.org/10.3390/pathogens9070558
Received: 5 June 2020 / Revised: 2 July 2020 / Accepted: 6 July 2020 / Published: 10 July 2020
(This article belongs to the Special Issue Biology and Pathology of Phytophthora infestans)
The pathogen Phytophthora infestans is responsible for worldwide catastrophic crop damage and discovery of new inhibitors of this organism is of paramount agricultural and industrial importance. Current strategies for crop treatment are inadequate with limitations of efficacy and market alternatives. Ellipticines have recently been reported to have fungicidal properties and have been assessed against P. infestans growth with promising results. We hereby report a probe of the ellipticine framework to investigate the alkyl subunit and screen a set ellipticines and derivatives to identify new lead compounds to act against P. infestans. A series of ellipticinium salt derivatives have been identified with exceptional growth inhibitory activity and apparent lack of toxicity towards a human cell-line surpassing the effect of known and marketed fungicides. This report identifies the potential of this natural product derivative as a novel fungicide. View Full-Text
Keywords: Phytophthora infestans; ellipticinium salts; isoellipticines; mycelial growth; oomycete; zoosporogenesis Phytophthora infestans; ellipticinium salts; isoellipticines; mycelial growth; oomycete; zoosporogenesis
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MDPI and ACS Style

McKee, M.L.; Zheng, L.; O’Sullivan, E.C.; Kehoe, R.A.; Doyle Prestwich, B.M.; Mackrill, J.J.; McCarthy, F.O. Synthesis and Evaluation of Novel Ellipticines and Derivatives as Inhibitors of Phytophthora infestans. Pathogens 2020, 9, 558. https://doi.org/10.3390/pathogens9070558

AMA Style

McKee ML, Zheng L, O’Sullivan EC, Kehoe RA, Doyle Prestwich BM, Mackrill JJ, McCarthy FO. Synthesis and Evaluation of Novel Ellipticines and Derivatives as Inhibitors of Phytophthora infestans. Pathogens. 2020; 9(7):558. https://doi.org/10.3390/pathogens9070558

Chicago/Turabian Style

McKee, Mary L.; Zheng, Limian; O’Sullivan, Elaine C.; Kehoe, Roberta A.; Doyle Prestwich, Barbara M.; Mackrill, John J.; McCarthy, Florence O. 2020. "Synthesis and Evaluation of Novel Ellipticines and Derivatives as Inhibitors of Phytophthora infestans" Pathogens 9, no. 7: 558. https://doi.org/10.3390/pathogens9070558

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