High-Risk Human Papillomaviruses and Epstein–Barr Virus in Colorectal Cancer and Their Association with Clinicopathological Status

Gupta, Ishita; Al Farsi, Halema; Jabeen, Ayesha; Skenderi, Faruk; Al-Thawadi, Hamda; AlAhmad, Yaman M.; Abdelhafez, Ibrahim; Al Moustafa, Ala-Eddin; Vranic, Semir

doi:10.3390/pathogens9060452

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High-Risk Human Papillomaviruses and Epstein–Barr Virus in Colorectal Cancer and Their Association with Clinicopathological Status

^1,†

^1,†,

¹,

¹,

¹,

Ala-Eddin Al Moustafa

^1,3,*

and

Semir Vranic

^1,*

College of Medicine, QU Health, Qatar University, 2713 Doha, Qatar

Department of Pathology, Clinical Center, University of Sarajevo, 71000 Sarajevo, Bosnia and Herzegovina

Biomedical Research Centre, Qatar University, 2713 Doha, Qatar

Authors to whom correspondence should be addressed.

^†

Both authors contributed equally to this manuscript.

Pathogens 2020, 9(6), 452; https://doi.org/10.3390/pathogens9060452

Received: 21 April 2020 / Revised: 21 May 2020 / Accepted: 28 May 2020 / Published: 8 June 2020

(This article belongs to the Special Issue Host-Pathogen Interaction in Colorectal Carcinogenesis)

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Abstract

Colorectal cancer (CRC) is a common malignancy with a high mortality rate worldwide. It is a complex, multifactorial disease that is strongly impacted by both hereditary and environmental factors. The role of microbes (e.g., viruses) in the pathogenesis of CRC is poorly understood. In the current study, we explored the status of high-risk human papillomaviruses (HPV) and Epstein–Barr virus (EBV) in a well-defined CRC cohort using immunohistochemistry and polymerase chain reaction assays. Our data showed that high-risk HPVs were common (~80%) and EBV had a low presence (14–25%) in the CRC samples. The most common high-risk HPVs are HPV16, 31, 18, 51, 52 and 45 genotypes. The co-presence of high-risk HPV and EBV was observed in ~16% of the sample population without any significant association with the clinicopathological variables. We conclude that high-risk HPVs are very prevalent in CRC samples while EBV positivity is relatively low. The co-expression of the two viruses was observed in a minority of cases and without any correlation with the studied parameters. Further studies are necessary to confirm the clinical relevance and potential therapeutic (preventive) effects of the observations reported herein. View Full-Text

Keywords: Epstein–Barr virus; human papillomaviruses; rectal cancer; immunohistochemistry; PCR

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MDPI and ACS Style

Gupta, I.; Al Farsi, H.; Jabeen, A.; Skenderi, F.; Al-Thawadi, H.; AlAhmad, Y.M.; Abdelhafez, I.; Al Moustafa, A.-E.; Vranic, S. High-Risk Human Papillomaviruses and Epstein–Barr Virus in Colorectal Cancer and Their Association with Clinicopathological Status. Pathogens 2020, 9, 452. https://doi.org/10.3390/pathogens9060452

AMA Style

Gupta I, Al Farsi H, Jabeen A, Skenderi F, Al-Thawadi H, AlAhmad YM, Abdelhafez I, Al Moustafa A-E, Vranic S. High-Risk Human Papillomaviruses and Epstein–Barr Virus in Colorectal Cancer and Their Association with Clinicopathological Status. Pathogens. 2020; 9(6):452. https://doi.org/10.3390/pathogens9060452

Chicago/Turabian Style

Gupta, Ishita, Halema Al Farsi, Ayesha Jabeen, Faruk Skenderi, Hamda Al-Thawadi, Yaman M. AlAhmad, Ibrahim Abdelhafez, Ala-Eddin Al Moustafa, and Semir Vranic. 2020. "High-Risk Human Papillomaviruses and Epstein–Barr Virus in Colorectal Cancer and Their Association with Clinicopathological Status" Pathogens 9, no. 6: 452. https://doi.org/10.3390/pathogens9060452

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High-Risk Human Papillomaviruses and Epstein–Barr Virus in Colorectal Cancer and Their Association with Clinicopathological Status

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