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Ethylicin Prevents Potato Late Blight by Disrupting Protein Biosynthesis of Phytophthora infestans

1
School of Life Sciences, Chongqing University, Chongqing 401331, China
2
School of Basic Medical Sciences, North Sichuan Medical College, Nanchong 637000, China
3
Department of Plant Pathology, University of Poonch Rawalakot AJK, Rawalakot AJK 12350, Pakistan
4
Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu 610000, China
5
Research Center for Atmospheric Environment, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Pathogens 2020, 9(4), 299; https://doi.org/10.3390/pathogens9040299
Received: 28 February 2020 / Revised: 16 April 2020 / Accepted: 17 April 2020 / Published: 19 April 2020
Phytophthora infestans, the causal agent of potato late blight, triggered the devastating Great Irish Famine that lasted from 1845 to 1852. Today, it is still the greatest threat to the potato yield. Ethylicin is a broad-spectrum biomimetic-fungicide. However, its application in the control of Phytophthora infestans is still unknown. In this study, we investigated the effects of ethylicin on Phytophthora infestans. We found that ethylicin inhibited the mycelial growth, sporulation capacity, spore germination and virulence of Phytophthora infestans. Furthermore, the integrated analysis of proteomics and metabolomics indicates that ethylicin may inhibit peptide or protein biosynthesis by suppressing both the ribosomal function and amino acid metabolism, causing an inhibitory effect on Phytophthora infestans. These observations indicate that ethylicin may be an anti-oomycete agent that can be used to control Phytophthora infestans. View Full-Text
Keywords: Phytophthora infestans; ethylicin; potato late blight; proteomics; ribosome; metabonomics; protein biosynthesis Phytophthora infestans; ethylicin; potato late blight; proteomics; ribosome; metabonomics; protein biosynthesis
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Zhang, S.; Zhang, M.; Khalid, A.R.; Li, L.; Chen, Y.; Dong, P.; Wang, H.; Ren, M. Ethylicin Prevents Potato Late Blight by Disrupting Protein Biosynthesis of Phytophthora infestans. Pathogens 2020, 9, 299.

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