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Human Papillomaviruses and Epstein–Barr Virus Interactions in Colorectal Cancer: A Brief Review

1
College of Medicine, QU Health, Qatar University, Doha 2713, Qatar
2
Biomedical Research Centre, Qatar University, Doha 2713, Qatar
*
Authors to whom correspondence should be addressed.
Both authors contributed equally to this review.
Pathogens 2020, 9(4), 300; https://doi.org/10.3390/pathogens9040300
Received: 9 March 2020 / Revised: 5 April 2020 / Accepted: 7 April 2020 / Published: 20 April 2020
(This article belongs to the Special Issue Host-Pathogen Interaction in Colorectal Carcinogenesis)
Human papillomaviruses (HPVs) and the Epstein–Barr virus (EBV) are the most common oncoviruses, contributing to approximately 10%–15% of all malignancies. Oncoproteins of high-risk HPVs (E5 and E6/E7), as well as EBV (LMP1, LMP2A and EBNA1), play a principal role in the onset and progression of several human carcinomas, including head and neck, cervical and colorectal. Oncoproteins of high-risk HPVs and EBV can cooperate to initiate and/or enhance epithelial-mesenchymal transition (EMT) events, which represents one of the hallmarks of cancer progression and metastasis. Although the role of these oncoviruses in several cancers is well established, their role in the pathogenesis of colorectal cancer is still nascent. This review presents an overview of the most recent advances related to the presence and role of high-risk HPVs and EBV in colorectal cancer, with an emphasis on their cooperation in colorectal carcinogenesis. View Full-Text
Keywords: EBV; high-risk HPV; oncovirus cooperation; colorectal cancer EBV; high-risk HPV; oncovirus cooperation; colorectal cancer
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MDPI and ACS Style

Fernandes, Q.; Gupta, I.; Vranic, S.; Al Moustafa, A.-E. Human Papillomaviruses and Epstein–Barr Virus Interactions in Colorectal Cancer: A Brief Review. Pathogens 2020, 9, 300.

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