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Open AccessReview

Neurological Aspects of HIV-1/HTLV-1 and HIV-1/HTLV-2 Coinfection

1
Evandro Chagas National Institute of Infectious Diseases (INI-FIOCRUZ), Brazilian Ministry of Health, Rio de Janeiro 21040-360, Brazil
2
Deolindo Couto Institute of Neurology (INDC), the Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22290-140, Brazil
Pathogens 2020, 9(4), 250; https://doi.org/10.3390/pathogens9040250
Received: 4 February 2020 / Revised: 15 March 2020 / Accepted: 27 March 2020 / Published: 28 March 2020
(This article belongs to the Special Issue HTLV-1 Disease)
Simultaneous infection by human immunodeficiency viruses (HIV) and human T-lymphotropic viruses (HTLV) are not uncommon since they have similar means of transmission and are simultaneously endemic in many populations. Besides causing severe immune dysfunction, these viruses are neuropathogenic and can cause neurological diseases through direct and indirect mechanisms. Many pieces of evidence at present show that coinfection may alter the natural history of general and, more specifically, neurological disorders through different mechanisms. In this review, we summarize the current evidence on the influence of coinfection on the progression and outcome of neurological complications of HTLV-1/2 and HIV-1. View Full-Text
Keywords: HIV; HTLV; AIDS; HAM/TSP; immunodeficiency; myelopathy; progression; T lymphocytes; transmission; coinfection HIV; HTLV; AIDS; HAM/TSP; immunodeficiency; myelopathy; progression; T lymphocytes; transmission; coinfection
MDPI and ACS Style

Araujo, A. .-C. Neurological Aspects of HIV-1/HTLV-1 and HIV-1/HTLV-2 Coinfection. Pathogens 2020, 9, 250.

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