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Aggregatibacter Actinomycetemcomitans: Clinical Significance of a Pathobiont Subjected to Ample Changes in Classification and Nomenclature

1
Department of Clinical Microbiology, Aarhus University Hospital, DK-8200 Aarhus N, Denmark
2
Department of Odontology, Division of Oral Microbiology, Umeå University, S-901 87 Umeå, Sweden
3
Department of Dentistry and Oral Health, Aarhus University, DK-8000 Aarhus C, Denmark
4
Department of Odontology, Division of Molecular Periodontology, Umeå University, S-901 87 Umeå, Sweden
*
Author to whom correspondence should be addressed.
Pathogens 2019, 8(4), 243; https://doi.org/10.3390/pathogens8040243
Received: 2 October 2019 / Revised: 10 November 2019 / Accepted: 13 November 2019 / Published: 18 November 2019
Aggregatibacter actinomycetemcomitans is a Gram-negative bacterium that is part of the oral microbiota. The aggregative nature of this pathogen or pathobiont is crucial to its involvement in human disease. It has been cultured from non-oral infections for more than a century, while its portrayal as an aetiological agent in periodontitis has emerged more recently. A. actinomycetemcomitans is one species among a plethora of microorganisms that constitute the oral microbiota. Although A. actinomycetemcomitans encodes several putative toxins, the complex interplay with other partners of the oral microbiota and the suppression of host response may be central for inflammation and infection in the oral cavity. The aim of this review is to provide a comprehensive update on the clinical significance, classification, and characterisation of A. actinomycetemcomitans, which has exclusive or predominant host specificity for humans. View Full-Text
Keywords: adherence; endocarditis; fimbriae; JP2; leukotoxin; periodontitis adherence; endocarditis; fimbriae; JP2; leukotoxin; periodontitis
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Nørskov-Lauritsen, N.; Claesson, R.; Jensen, A.B.; Åberg, C.H.; Haubek, D. Aggregatibacter Actinomycetemcomitans: Clinical Significance of a Pathobiont Subjected to Ample Changes in Classification and Nomenclature. Pathogens 2019, 8, 243.

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