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Pathogens 2018, 7(2), 40; https://doi.org/10.3390/pathogens7020040

The Microenvironment in Epstein–Barr Virus-Associated Malignancies

1
Molecular Pathology Unit, Cancer Research Centre, Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia
2
Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, code EA10, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
3
Department of Medical Sciences, School of Healthcare and Medical Sciences, Sunway University, Jalan Universiti, Bandar Sunway, 47500 Selangor Darul Ehsan, Malaysia
*
Author to whom correspondence should be addressed.
Received: 28 February 2018 / Revised: 8 April 2018 / Accepted: 11 April 2018 / Published: 13 April 2018
(This article belongs to the Special Issue Emerging Topics in Epstein-Barr virus-Associated Diseases)
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Abstract

The Epstein–Barr virus (EBV) can cause a wide variety of cancers upon infection of different cell types and induces a highly variable composition of the tumor microenvironment (TME). This TME consists of both innate and adaptive immune cells and is not merely an aspecific reaction to the tumor cells. In fact, latent EBV-infected tumor cells utilize several specific mechanisms to form and shape the TME to their own benefit. These mechanisms have been studied largely in the context of EBV+ Hodgkin lymphoma, undifferentiated nasopharyngeal carcinoma, and EBV+ gastric cancer. This review describes the composition, immune escape mechanisms, and tumor cell promoting properties of the TME in these three malignancies. Mechanisms of susceptibility which regularly involve genes related to immune system function are also discussed, as only a small proportion of EBV-infected individuals develops an EBV-associated malignancy. View Full-Text
Keywords: Epstein-Barr virus; tumor microenvironment; Hodgkin lymphoma; undifferentiated nasopharyngeal carcinoma; gastric carcinoma; immune escape; susceptibility Epstein-Barr virus; tumor microenvironment; Hodgkin lymphoma; undifferentiated nasopharyngeal carcinoma; gastric carcinoma; immune escape; susceptibility
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Tan, G.W.; Visser, L.; Tan, L.P.; Berg, A.; Diepstra, A. The Microenvironment in Epstein–Barr Virus-Associated Malignancies. Pathogens 2018, 7, 40.

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